Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1503

MIN ACTIVATION

0.0

Details List

#708 Drug Resistance Mechanisms in Cancer

#1476 Feature #1476

#463 Feature #463

#1844 Feature #1844

#436 Feature #436

#1425 Feature 1425

#997 Feature #997

#268 Feature #268

#2132 Feature #2132

#2738 Feature #2738

#568 Feature #568

#405 Feature #405

#2265 Feature #2265

#2460 Feature #2460

#766 Feature #766

#2907 Feature #2907

#150 Feature #150

#981 Feature #981

#1929 Feature #1929

#916 Feature #916

#887 Feature #887

#74 Feature #74

#84 Feature #84

#1245 Feature #1245

#2354 Feature #2354

#698 Feature #698

#1721 Feature #1721

#2755 Feature #2755

#2732 Feature #2732

#2759 Feature #2759

#659 Feature #659

#337 Feature #337

#1161 Feature #1161

#1116 Feature #1116

#2803 Feature #2803

#1304 Feature #1304

#356 Feature #356

#627 Feature #627

#2255 Feature #2255

#283 Feature #283

#2561 Feature #2561

#1802 Feature #1802

#2108 Feature #2108

#1449 Feature #1449

#2419 Feature #2419

#2698 Feature #2698

#1623 Feature #1623

#1925 Feature #1925

#237 Feature #237

#164 Feature 164

#185 Feature #185

#2608 Feature #2608

#2802 Feature #2802

#179 Feature #179

#1990 Feature #1990

#824 Feature #824

#868 Feature #868

#1042 Feature #1042

#1805 Feature #1805

#1028 Feature #1028

#2797 Feature #2797

#662 Feature #662

#738 Feature 738

#1829 Feature #1829

#92 Feature #92

#2432 Feature #2432

#48 Feature #48

#2637 Feature #2637

#1671 Feature #1671

#50 Feature #50

#2338 Feature #2338

#740 Feature #740

#1965 Feature #1965

#2914 Feature #2914

#1834 Feature #1834

#2889 Feature #2889

#1588 Feature #1588

#1410 Feature #1410

#3060 Feature #3060

#506 Feature #506

#2070 Feature #2070

#2410 Feature #2410

#2559 Feature #2559

#2984 Feature #2984

#2022 Feature #2022

#897 Feature #897

#1548 Feature #1548

#2548 Feature #2548

#1130 Feature #1130

#1926 Feature #1926

#2792 Feature #2792

#1087 Feature #1087

#100 Feature #100

#2182 Feature #2182

#2368 Feature #2368

#2940 Feature #2940

#1452 Feature #1452

#639 Feature #639

#1631 Feature #1631

#1156 Feature #1156

#1486 Feature #1486

#2319 Feature #2319

#1630 Feature #1630

#2671 Feature #2671

#2566 Feature #2566

#1628 Feature #1628

#1184 Feature #1184

#1328 Feature #1328

#894 Feature #894

#2353 Feature #2353

#1713 Feature #1713

#1737 Feature #1737

#2598 Feature #2598

#140 Feature #140

#138 Feature #138

#1574 Feature #1574

#3011 Feature #3011

#972 Feature #972

#1912 Feature #1912

#1457 Feature #1457

#1700 Feature #1700

#1447 Feature #1447

#757 Feature #757

#2524 Feature #2524

#1082 Feature #1082

#2327 Feature #2327

#1869 Feature #1869

#1828 Feature #1828

#867 Feature #867

#2336 Feature #2336

#632 Feature #632

#2491 Feature #2491

#2740 Feature #2740

#2126 Feature #2126

#2334 Feature #2334

#1822 Feature 1822

#95 Feature #95

#1910 Feature #1910

#806 Feature #806

#692 Feature #692

#2687 Feature #2687

#1703 Feature #1703

#1487 Feature #1487

#374 Medical Imaging and Oncology

#1781 Feature #1781

#1870 Feature #1870

#52 Feature #52

#1695 Feature #1695

#1735 Feature #1735

#1658 Feature #1658

#760 Feature #760

#1749 Feature #1749

#598 Feature #598

#2500 Feature #2500

#2877 Feature #2877

#2824 Feature #2824

#343 Feature #343

#2436 Feature #2436

#3007 Feature #3007

#2931 Feature #2931

#1136 Feature #1136

#579 Feature #579

#210 Feature #210

#979 Feature #979

#552 Feature #552

#2013 Feature #2013

#1609 Feature #1609

#427 Feature #427

#507 Feature #507

#699 Feature #699

#1992 Feature #1992

#430 Feature #430

#2174 Feature #2174

#2519 Feature #2519

#2887 Feature #2887

#1329 Feature #1329

#2372 Feature #2372

#1196 Feature #1196

#1139 Feature #1139

#2848 Feature #2848

#746 Feature #746

#2992 Feature #2992

#1363 Feature #1363

#923 Feature #923

#1796 Feature #1796

#2638 Feature #2638

#661 Feature #661

#1853 Feature #1853

#2421 Feature #2421

#389 Feature 389

#2124 Feature #2124

#2972 Sensory-Motor Integration

#2918 Feature #2918

#2404 Feature #2404

#2880 Feature #2880

#1456 Feature #1456

#939 Feature #939

#690 Feature #690

#323 Feature #323

#3000 Feature #3000

#2737 Feature #2737

#238 Feature #238

#857 Feature #857

#2945 Feature 2945

#838 Feature #838

#1383 Feature #1383

#2567 Feature #2567

#500 Feature #500

#2366 Feature #2366

#1243 Feature #1243

#79 Feature #79

#2599 Feature #2599

#2223 Feature #2223

#668 Feature #668

#1407 Feature #1407

#2090 Feature #2090

#475 Feature #475

#38 Feature #38

#144 Feature #144

#1765 Feature #1765

#1691 Feature #1691

#2356 Feature #2356

#90 Feature #90

#801 Feature #801

#2471 Feature #2471

#317 Feature #317

#779 Feature #779

#350 Feature #350

#2264 Feature #2264

#344 Feature #344

#502 Feature #502

#3039 Feature #3039

#108 Feature #108

#1492 Feature #1492

#2823 Feature #2823

#2340 Feature #2340

#2588 Feature #2588

#2280 Feature #2280

#2534 Feature #2534

#1353 Feature #1353

#634 Feature #634

#543 Feature #543

#548 Feature #548

#2593 Feature #2593

#2826 Feature #2826

#578 Feature #578

#990 Feature #990

#2109 Feature #2109

#768 Feature #768

#1936 Feature #1936

#2323 Feature #2323

#1515 Feature #1515

#1967 Feature #1967

#2935 Feature #2935

#2719 Feature #2719

#1752 Feature #1752

#1753 Feature #1753

#761 Feature #761

#2613 Feature #2613

#1088 Feature #1088

#322 Feature #322

#2033 Feature #2033

#2903 Feature #2903

#716 Feature #716

#2582 Feature #2582

#158 Feature #158

#618 Feature #618

#2119 Feature #2119

#951 Feature #951

#890 Feature #890

#1294 Feature #1294

#2779 Feature #2779

#1198 Feature #1198

#2490 Feature #2490

#1132 Feature #1132

#1391 Feature #1391

#1483 Feature #1483

#1786 Feature #1786

#1293 Feature #1293

#23 Neuronal Circuitry and Cellular Processes

#1586 Feature #1586

#1518 Feature #1518

#932 Feature #932

#3071 Feature #3071

#1182 Feature #1182

#2526 Feature #2526

#96 Feature #96

#1535 Feature #1535

#1972 Feature 1972

#1080 Feature #1080

#1114 Feature #1114

#1099 Feature #1099

#1850 Feature #1850

#2485 Feature #2485

#793 Feature #793

#695 Feature #695

#2893 Feature #2893

#1317 Feature #1317

#842 Feature #842

#614 Feature #614

#1195 Feature #1195

#302 Feature #302

#2846 Feature #2846

#928 Feature #928

#986 Feature #986

#437 Feature #437

#1170 Feature #1170

#313 Feature #313

#2155 Feature #2155

#2251 Feature #2251

#2677 Feature #2677

#111 Feature #111

#1225 Feature #1225

#536 Feature #536

#118 Feature #118

#2721 Feature #2721

#777 Feature #777

#1891 Feature #1891

#413 Feature #413

#2141 Feature #2141

#799 Feature #799

#2953 Feature #2953

#1291 Feature #1291

#592 Feature #592

#1398 Feature #1398

#2504 Feature #2504

#783 Feature #783

#2253 Feature #2253

#1025 Feature #1025

#152 Feature #152

#1327 Feature #1327

#3017 Feature #3017

#637 Feature #637

#2348 Feature #2348

#640 Feature #640

#2148 Feature #2148

#3041 Feature #3041

#2539 Feature #2539

#1180 Feature #1180

#1009 Feature #1009

#2676 Feature #2676

#876 Feature #876

#2429 Feature #2429

#1684 Feature #1684

#334 Feature #334

#1596 Feature #1596

#558 Feature #558

#2250 Feature 2250

#2553 Feature #2553

#112 Feature #112

#866 Feature #866

#1420 Feature #1420

#3006 Feature #3006

#2361 Feature #2361

#2963 Feature #2963

#1262 Feature #1262

#2993 Feature #2993

#1063 Feature #1063

#295 Feature #295

#1970 Feature #1970

#1905 Feature #1905

#2077 Feature #2077

#835 Feature #835

#2869 Feature #2869

#181 Feature #181

#3043 Feature #3043

#1445 Feature #1445

#1464 Feature #1464

#1434 Feature #1434

#1141 Feature #1141

#693 Feature #693

#1113 Feature #1113

#816 Feature #816

#1966 Feature #1966

#771 Feature #771

#2377 Feature #2377

#1393 Feature #1393

#527 Feature #527

#1390 Feature #1390

#2933 Feature #2933

#886 Feature #886

#42 Feature #42

#1101 Feature #1101

#473 Feature #473

#2746 Feature #2746

#1529 Feature #1529

#2807 Feature #2807

#1656 Feature #1656

#2241 Feature #2241

#215 Feature #215

#2138 Feature #2138

#3009 Feature #3009

#1974 Feature #1974

#1379 Feature #1379

#938 Feature #938

#2114 Feature #2114

#203 Feature #203

#850 Feature #850

#180 Feature #180

#1604 Feature #1604

#2771 Feature #2771

#2722 Feature #2722

#2179 Feature #2179

#2683 Feature #2683

#1725 Feature #1725

#901 Feature #901

#1867 Feature #1867

#444 Feature #444

#2968 Feature #2968

#1127 Feature #1127

#2706 Feature #2706

#1762 Feature #1762

#1268 Feature #1268

#241 Feature #241

#395 Feature #395

#2617 Feature #2617

#2606 Feature #2606

#288 Feature #288

#2393 Feature #2393

#2997 Feature #2997

#1323 Feature #1323

#2208 Feature #2208

#2424 Feature #2424

#1377 Feature #1377

#1916 Feature #1916

#1594 Feature #1594

#2523 Feature #2523

#1611 Feature #1611

#1961 Feature #1961

#2171 Molecular and Cellular Biological Processes

#2958 Feature #2958

#1192 Feature #1192

#805 Feature #805

#2439 Feature #2439

#2785 Feature #2785

#24 Feature #24

#2050 Feature #2050

#2286 Feature #2286

#2557 Feature #2557

#1701 Feature #1701

#1913 Feature #1913

#1221 Feature #1221

#2507 Feature #2507

#1232 Feature #1232

#2502 Feature #2502

#2305 Feature #2305

#2844 Feature #2844

#1385 Feature #1385

#1851 Feature #1851

#1642 Feature #1642

#826 Feature #826

#515 Feature #515

#2854 Feature #2854

#2602 Feature #2602

#2247 Feature #2247

#1714 Feature #1714

#2320 Feature #2320

#2245 Feature #2245

#2391 Feature #2391

#1422 Feature #1422

#1152 Feature #1152

#1539 Feature #1539

#291 Feature #291

#1444 Feature #1444

#1880 Feature #1880

#2335 Feature #2335

#2793 Feature #2793

#1381 Feature #1381

#675 Feature #675

#2291 Feature #2291

#114 Feature #114

#1864 Feature #1864

#2062 Feature #2062

#1935 Feature #1935

#1901 Feature #1901

#976 Feature #976

#960 Feature #960

#107 Feature #107

#2633 Feature #2633

#3058 Feature #3058

#2817 Feature #2817

#2999 Feature #2999

#3036 Feature #3036

#2433 Feature 2433

#971 Feature #971

#533 Feature #533

#1414 Feature #1414

#1234 Feature #1234

#1258 Feature #1258

#1020 Feature #1020

#94 Feature #94

#480 Feature #480

#2086 Feature #2086

#2369 Feature #2369

#1431 Feature #1431

#1351 Feature #1351

#1085 Feature #1085

#3070 Spiritual and Holistic Care in Healthcare

#2284 Feature #2284

#2446 Feature #2446

#1392 Feature #1392

#2707 Feature #2707

#811 Feature #811

#2669 Feature #2669

#2283 Feature #2283

#1625 Feature #1625

#2665 Feature #2665

#2339 Feature #2339

#2531 Feature #2531

#2330 Feature #2330

#2518 Feature #2518

#2206 Feature #2206

#207 Feature #207

#2990 Feature #2990

#3044 Feature #3044

#168 Feature #168

#87 Feature #87

#963 Feature #963

#1987 Feature #1987

#2397 Feature #2397

#1666 Feature #1666

#2980 Feature #2980

#914 Feature #914

#1921 Feature #1921

#1818 Feature #1818

#2399 Feature #2399

#1131 Feature #1131

#2316 Feature #2316

#1160 Feature #1160

#2692 Feature #2692

#2034 Feature #2034

#2925 Feature #2925

#81 Feature #81

#1438 Feature #1438

#1462 Feature #1462

#657 Feature #657

#883 Feature #883

#2562 Feature #2562

#250 Feature #250

#2987 Feature #2987

#1112 Feature #1112

#1522 Feature #1522

#136 Feature #136

#2408 Feature #2408

#2750 Feature #2750

#565 Feature #565

#1482 Feature #1482

#2560 Feature #2560

#1076 Feature #1076

#309 Feature #309

#2111 Feature #2111

#1049 Feature #1049

#2503 Feature #2503

#1523 Feature #1523

#1367 Feature #1367

#424 Feature #424

#2288 Feature #2288

#2989 Feature #2989

#1797 Feature #1797

#2401 Feature #2401

#1142 Feature #1142

#2497 Feature #2497

#1355 Feature #1355

#1129 Feature #1129

#1755 Feature #1755

#1709 Feature #1709

#2830 Feature #2830

#2462 Feature #2462

#773 Feature #773

#187 Feature #187

#2190 Feature #2190

#977 Feature #977

#2278 Feature #2278

#511 Feature #511

#285 Feature #285

#1166 Feature #1166

#2786 Feature #2786

#2092 Feature #2092

#1187 Feature #1187

#701 Feature #701

#2234 Feature #2234

#1175 Feature #1175

#1481 Feature #1481

#2384 Feature #2384

#1973 Feature #1973

#2551 Feature #2551

#2216 Feature #2216

#1964 Feature #1964

#1988 Feature #1988

#2868 Feature #2868

#2173 Feature #2173

#2947 Feature #2947

#2039 Feature #2039

#2337 Feature #2337

#1546 Feature #1546

#2506 Feature #2506

#1478 Feature #1478

#2908 Feature #2908

#1004 Feature #1004

#1537 Feature #1537

#2027 Feature #2027

#2309 Feature #2309

#1286 Feature #1286

#2715 Feature #2715

#2176 Feature #2176

#1494 Feature #1494

#1830 Feature #1830

#1014 Feature #1014

#1069 Feature #1069

#113 Feature #113

#2621 Feature #2621

#1512 Feature #1512

#3028 Feature #3028

#1711 Feature #1711

#643 Feature #643

#686 Feature #686

#1727 Feature #1727

#1264 Feature #1264

#1634 Feature #1634

#2658 Feature #2658

#2649 Feature #2649

#2101 Feature #2101

#1119 Feature #1119

#457 Feature #457

#514 Feature #514

#1722 Feature #1722

#896 Feature #896

#1239 Feature #1239

#2609 Feature #2609

#224 Feature #224

#2481 Feature #2481

#1645 Feature #1645

#282 Feature #282

#2205 Feature #2205

#1105 Feature #1105

#2525 Feature #2525

#78 Feature #78

#1342 Feature #1342

#1767 Feature #1767

#484 Feature #484

#148 Feature 148

#791 Feature #791

#2435 Feature #2435

#934 Feature #934

#2739 Feature #2739

#1017 Feature #1017

#1704 Feature #1704

#1933 Feature #1933

#1086 Feature #1086

#2055 Feature #2055

#2580 Feature #2580

#2696 Feature #2696

#2538 Feature #2538

#2468 Feature #2468

#615 Feature #615

#2009 Feature #2009

#2546 Feature #2546

#2592 Feature #2592

#1800 Feature #1800

#1979 Feature #1979

#483 Feature #483

#2589 Feature #2589

#1995 Feature #1995

#251 Feature #251

#1265 Feature #1265

#532 Feature #532

#672 Feature #672

#1886 Feature #1886

#2359 Feature #2359

#362 Feature #362

#97 Feature #97

#1432 Feature #1432

#1279 Feature 1279

#1229 Feature #1229

#2930 Feature #2930

#2194 Feature #2194

#1311 Molecular Mechanisms and Biological Processes

#209 Feature #209

#196 Feature #196

#1644 Feature #1644

#810 Feature #810

#440 Feature #440

#988 Feature #988

#188 Feature #188

#1640 Feature #1640

#1315 Feature #1315

#1469 Feature #1469

#1859 Feature #1859

#1078 Feature #1078

#1517 Feature #1517

#874 Feature #874

#2063 Feature #2063

#1944 Feature #1944

#2645 Feature #2645

#2198 Feature #2198

#2386 Feature 2386

#813 Feature #813

#519 Feature #519

#898 Feature #898

#383 Feature #383

#2300 Feature #2300

#961 Feature #961

#121 Feature #121

#780 Feature #780

#2772 Feature #2772

#1395 Feature #1395

#2279 Feature #2279

#25 Feature #25

#2390 Feature #2390

#1686 Feature #1686

#2528 Feature #2528

#2977 Feature #2977

#989 Feature #989

#27 Feature #27

#1788 Feature #1788

#941 Feature #941

#1473 Feature #1473

#422 Feature #422

#137 Feature #137

#105 Feature #105

#1624 Feature #1624

#630 Feature #630

#41 Feature #41

#1077 Feature #1077

#1804 Feature #1804

#2657 Feature #2657

#1994 Feature #1994

#325 Feature #325

#1561 Feature #1561

#1690 Feature #1690

#952 Feature #952

#2694 Feature #2694

#126 Feature #126

#666 Feature #666

#1949 Feature #1949

#985 Feature #985

#1920 Feature #1920

#2427 Feature #2427

#2100 Feature #2100

#1559 Feature #1559

#1041 Feature #1041

#863 Feature #863

#1799 Feature #1799

#1178 Feature #1178

#582 Feature #582

#1746 Feature #1746

#2451 Feature #2451

#1110 Feature #1110

#2890 Feature #2890

#2112 Feature #2112

#64 Feature #64

#648 Feature #648

#891 Feature #891

#2822 Feature #2822

#221 Feature #221

#936 Feature #936

#2699 Feature #2699

#1687 Feature #1687

#929 Feature #929

#58 Feature #58

#443 Feature #443

#651 Feature #651

#2821 Feature #2821

#287 Feature #287

#1747 Feature #1747

#2292 Feature 2292

#2440 Feature #2440

#1205 Feature #1205

#2660 Feature #2660

#1510 Feature #1510

#3045 Feature #3045

#1657 Feature #1657

#2510 Feature #2510

#2038 Feature #2038

#186 Feature #186

#1339 Feature #1339

#1633 Feature #1633

#1600 Feature #1600

#3015 Feature #3015

#411 Feature #411

#2311 Feature #2311

#2287 Feature #2287

#2579 Feature #2579

#787 Feature #787

#456 Feature #456

#1094 Feature #1094

#547 Feature #547

#249 Feature #249

#715 Feature #715

#2998 Feature #2998

#1399 Feature #1399

#576 Feature #576

#1653 Feature #1653

#2107 Feature #2107

#1993 Feature #1993

#2004 Feature #2004

#2298 Feature #2298

#2842 Feature #2842

#1470 Feature #1470

#892 Feature #892

#1943 Feature #1943

#1043 Feature #1043

#1231 Feature #1231

#3032 Feature #3032

#1073 Feature #1073

#1553 Feature #1553

#1334 Feature #1334

#2204 Feature #2204

#1815 Feature #1815

#1914 Feature #1914

#2741 Feature #2741

#649 Feature #649

#1980 Feature #1980

#1408 Feature #1408

#834 Feature #834

#2346 Feature #2346

#271 Feature #271

#211 Feature #211

#781 Feature #781

#2007 Developmental Disparities & Intervention

#1115 Feature 1115

#485 Feature #485

#1458 Feature #1458

#379 Feature #379

#2227 Feature #2227

#1601 Feature #1601

#2242 Feature #2242

#262 Feature #262

#2153 Feature #2153

#2744 Feature #2744

#1292 Feature #1292

#240 Feature #240

#171 Feature #171

#1306 Feature #1306

#2276 Feature #2276

#1813 Feature #1813

#336 Feature #336

#1362 Feature #1362

#665 Feature #665

#2008 Feature #2008

#1348 Feature #1348

#2796 Feature #2796

#284 Feature #284

#937 Feature #937

#1361 Feature #1361

#913 Feature #913

#2717 Feature #2717

#1946 Feature #1946

#1699 Feature #1699

#2329 Feature #2329

#1109 Feature #1109

#2088 Feature #2088

#1521 Feature #1521

#1230 Feature #1230

#1991 Feature #1991

#1058 Feature #1058

#1680 Feature #1680

#1706 Feature #1706

#110 Feature #110

#2728 Feature #2728

#254 Feature #254

#1820 Feature #1820

#1021 Feature #1021

#1227 Feature #1227

#2950 Feature #2950

#1270 Feature #1270

#1646 Feature #1646

#2282 Feature #2282

#2965 Feature #2965

#958 Feature #958

#1888 Feature #1888

#2607 Feature #2607

#673 Feature #673

#1971 Feature #1971

#1441 Feature #1441

#3001 Feature #3001

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#905 Feature #905

#1739 Feature #1739

#1874 Feature #1874

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#2268 Feature #2268

#2394 Feature #2394

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#1045 Feature #1045

#2776 Feature #2776

#2160 Feature #2160

#2929 Feature #2929

#1378 Feature #1378

#1768 Feature #1768

#2541 Feature #2541

#182 Feature #182

#2158 Feature #2158

#1484 Feature #1484

#856 Feature #856

#1771 Feature #1771

#2382 Feature #2382

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#2374 Feature #2374

#1256 Feature #1256

#2045 Feature #2045

#2520 Feature #2520

#252 Feature #252

#2060 Feature #2060

#2625 Feature #2625

#1200 Feature #1200

#508 Feature #508

#391 Feature #391

#877 Feature #877

#2924 Feature #2924

#597 Feature #597

#1138 Feature #1138

#1388 Feature #1388

#1719 Feature #1719

#2845 Feature #2845

#633 Feature #633

#2026 Feature #2026

#909 Feature #909

#2939 Feature #2939

#1428 Feature #1428

#1181 Feature #1181

#2689 Feature 2689

#256 Feature #256

#1900 Feature #1900

#2673 Feature #2673

#1889 Feature #1889

#3068 Feature #3068

#812 Feature #812

#1824 Feature #1824

#2690 Feature #2690

#492 Feature #492

#710 Feature #710

#2618 Feature #2618

#882 Feature #882

#613 Feature #613

#1451 Feature #1451

#557 Feature #557

#1766 Feature #1766

#2932 Feature #2932

#1140 Feature #1140

#2662 Feature #2662

#1061 Feature #1061

#167 Feature #167

#1590 Feature #1590

#2040 Feature #2040

#2790 Feature #2790

#1039 Feature #1039

#1236 Feature #1236

#331 Feature #331

#1698 Feature #1698

#2934 Feature #2934

#1514 Feature #1514

#1054 Feature #1054

#1618 Feature #1618

#305 Feature #305

#2533 Feature #2533

#1544 Feature #1544

#911 Feature #911

#1144 Feature #1144

#166 Feature #166

#2904 Feature #2904

#1919 Feature #1919

#264 Feature #264

#102 Feature #102

#1738 Feature #1738

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Document Content

Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.
Polyamines are essential for tumor growth; consequently, agents that interfere with their metabolisms have been developed as antineoplastic agents. Diethylnorspermine (DENSPM) is one such agent. A focused Phase I clinical trial in patients with advanced non-small cell lung cancer was undertaken. Twenty-nine patients were treated with DENSPM using a dosing schedule of once daily for 5 days. Doses ranged from 25 mg/m(2)/day to 231 mg/m(2)/day. The dose-limiting toxicity was determined to be gastrointestinal including asthenia, abdominal cramps, diarrhea, and nausea. The maximal tolerated dose was 185 mg/m(2)/day for 5 days. At drug dosages for which it was possible to estimate, serum half-life ranged from 0.5 to 3.7 h without apparent dose dependence. Maximal serum concentrations increased with dosage. However, the increase was greater than the proportional increase of the administered dose. There were no objective disease responses observed during the Phase I trial. The results of the Phase I clinical trial suggest that DENSPM can safely be administered to patients with minimal toxicity. Furthermore, the observed dose-limiting toxicity is unique to DENSPM, thus underscoring the potential for DENSPM to be a suitable agent for chemotherapy in combination with agents possessing different spectrums of toxicities.

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