Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1551

MIN ACTIVATION

0.0

Details List

#708 Drug Resistance Mechanisms in Cancer

#1606 Feature #1606

#334 Feature #334

#2023 Feature #2023

#2309 Feature #2309

#2599 Feature #2599

#1824 Feature #1824

#1805 Feature #1805

#1492 Feature #1492

#698 Feature #698

#1476 Feature #1476

#1425 Feature 1425

#1085 Feature #1085

#84 Feature #84

#2467 Feature #2467

#911 Feature #911

#916 Feature #916

#50 Feature #50

#2997 Feature #2997

#1431 Feature #1431

#2064 Feature #2064

#2100 Feature #2100

#436 Feature #436

#1328 Feature #1328

#600 Feature #600

#2481 Feature #2481

#2903 Feature #2903

#1087 Feature #1087

#2254 Feature #2254

#392 Feature #392

#2972 Sensory-Motor Integration

#2575 Feature #2575

#2732 Feature #2732

#264 Feature #264

#2250 Feature 2250

#1844 Feature #1844

#1517 Feature #1517

#1834 Feature #1834

#1379 Feature #1379

#672 Feature #672

#2138 Feature #2138

#1550 Feature #1550

#389 Feature 389

#2270 Feature #2270

#2709 Feature #2709

#2608 Feature #2608

#112 Feature #112

#1457 Feature #1457

#2237 Feature #2237

#2592 Feature #2592

#31 Feature #31

#405 Feature #405

#2340 Feature #2340

#19 Feature #19

#2178 Feature #2178

#771 Feature #771

#886 Feature #886

#1130 Feature #1130

#16 Feature #16

#2208 Feature #2208

#457 Feature #457

#872 Feature #872

#1537 Feature #1537

#1549 Feature #1549

#78 Feature #78

#2033 Feature #2033

#723 Feature #723

#1494 Feature #1494

#1318 Feature #1318

#2910 Feature #2910

#2790 Feature #2790

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#1192 Feature #1192

#641 Feature #641

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#1765 Feature #1765

#2531 Feature #2531

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#541 Feature #541

#565 Feature #565

#158 Feature #158

#987 Feature #987

#2039 Feature #2039

#2554 Feature #2554

#2646 Feature #2646

#138 Feature #138

#647 Feature #647

#2555 Feature 2555

#1351 Feature #1351

#2973 Feature #2973

#976 Feature #976

#2354 Feature #2354

#463 Feature #463

#2416 Feature #2416

#892 Feature #892

#2010 Feature #2010

#799 Feature #799

#1452 Feature #1452

#2551 Feature #2551

#1607 Feature #1607

#1065 Feature #1065

#2401 Feature #2401

#2562 Feature #2562

#2050 Feature #2050

#2706 Feature #2706

#1516 Feature #1516

#1671 Feature #1671

#2740 Feature #2740

#2171 Molecular and Cellular Biological Processes

#836 Feature #836

#1418 Feature #1418

#1017 Feature #1017

#1870 Feature #1870

#92 Feature #92

#1628 Feature #1628

#2758 Feature #2758

#1994 Feature #1994

#1424 Feature #1424

#1996 Feature #1996

#23 Neuronal Circuitry and Cellular Processes

#200 Feature #200

#107 Feature #107

#952 Feature #952

#687 Feature #687

#856 Feature #856

#1501 Feature #1501

#609 Feature #609

#2685 Feature #2685

#1802 Feature #1802

#1496 Feature #1496

#548 Feature #548

#1548 Feature #1548

#1975 Feature #1975

#329 Feature #329

#1913 Feature #1913

#1960 Feature #1960

#627 Feature #627

#1049 Feature #1049

#1680 Feature #1680

#2533 Feature #2533

#237 Feature #237

#2359 Feature #2359

#374 Medical Imaging and Oncology

#2030 Feature #2030

#587 Feature #587

#870 Feature #870

#642 Feature #642

#1856 Feature #1856

#1014 Feature #1014

#515 Feature #515

#97 Feature #97

#510 Feature #510

#1586 Feature #1586

#1896 Feature #1896

#777 Feature #777

#3060 Feature #3060

#2694 Feature #2694

#562 Feature #562

#1420 Feature #1420

#1971 Feature #1971

#2908 Feature #2908

#34 Feature #34

#2848 Feature #2848

#117 Feature #117

#2497 Feature #2497

#1365 Feature #1365

#421 Feature #421

#1235 Feature #1235

#146 Feature #146

#1512 Feature #1512

#1926 Feature #1926

#1337 Feature #1337

#1414 Feature #1414

#1927 Feature #1927

#2966 Feature #2966

#325 Feature #325

#3007 Feature #3007

#1266 Feature #1266

#981 Feature #981

#1127 Feature #1127

#1786 Feature #1786

#1393 Feature #1393

#1109 Feature #1109

#637 Feature #637

#1321 Feature #1321

#1729 Feature #1729

#3049 Feature #3049

#2338 Feature #2338

#1406 Feature #1406

#437 Feature #437

#511 Feature #511

#1974 Feature #1974

#1965 Feature #1965

#824 Feature #824

#2320 Feature #2320

#958 Feature #958

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#2027 Feature #2027

#2112 Feature #2112

#1152 Feature #1152

#1893 Feature #1893

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#2038 Feature #2038

#1262 Feature #1262

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#791 Feature #791

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#315 Feature #315

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#422 Feature #422

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#1210 Feature #1210

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#1760 Feature #1760

#2391 Feature #2391

#618 Feature #618

#1216 Feature #1216

#1486 Feature #1486

#2230 Feature #2230

#475 Feature #475

#2746 Feature #2746

#2043 Feature #2043

#2874 Feature #2874

#2090 Feature #2090

#2914 Feature #2914

#2657 Feature #2657

#2321 Feature #2321

#1677 Feature #1677

#1069 Feature #1069

#2696 Feature #2696

#1358 Feature #1358

#409 Feature #409

#1043 Feature #1043

#60 Feature #60

#1872 Feature #1872

#539 Feature #539

#2408 Feature #2408

#2559 Feature #2559

#2265 Feature #2265

#743 Feature #743

#2083 Feature #2083

#1142 Feature #1142

#1221 Feature #1221

#1766 Feature #1766

#938 Feature #938

#235 Feature #235

#2868 Feature #2868

#828 Feature #828

#2073 Feature #2073

#971 Feature #971

#635 Feature #635

#1009 Feature #1009

#1565 Feature #1565

#1749 Feature #1749

#1526 Feature #1526

#198 Feature #198

#2633 Feature #2633

#340 Feature #340

#1039 Feature #1039

#2797 Feature #2797

#2993 Feature #2993

#1995 Feature #1995

#1867 Feature #1867

#2279 Feature #2279

#383 Feature #383

#620 Feature #620

#1218 Feature #1218

#2846 Feature #2846

#537 Feature #537

#832 Feature #832

#3071 Feature #3071

#166 Feature #166

#149 Feature #149

#1967 Feature #1967

#871 Feature #871

#1294 Feature #1294

#38 Feature #38

#2150 Feature #2150

#1521 Feature #1521

#2523 Feature #2523

#1889 Feature #1889

#256 Feature #256

#233 Feature #233

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#2509 Feature #2509

#1497 Feature #1497

#1514 Feature #1514

#699 Feature #699

#1624 Feature #1624

#783 Feature #783

#2438 Feature #2438

#1843 Feature #1843

#185 Feature #185

#1696 Feature #1696

#2179 Feature #2179

#1004 Feature #1004

#2567 Feature #2567

#740 Feature #740

#2183 Feature #2183

#1633 Feature #1633

#882 Feature #882

#1139 Feature #1139

#659 Feature #659

#648 Feature #648

#838 Feature #838

#2817 Feature #2817

#632 Feature #632

#633 Feature #633

#1706 Feature #1706

#519 Feature #519

#2181 Feature #2181

#1044 Feature #1044

#2055 Feature #2055

#64 Feature #64

#2510 Feature #2510

#160 Feature #160

#144 Feature #144

#1901 Feature #1901

#859 Feature #859

#2899 Feature #2899

#1990 Feature #1990

#1933 Feature #1933

#1445 Feature #1445

#1381 Feature #1381

#2472 Feature #2472

#12 Feature #12

#1390 Feature #1390

#811 Feature #811

#2348 Feature #2348

#3006 Feature #3006

#1317 Feature #1317

#1860 Feature #1860

#1058 Feature #1058

#199 Feature #199

#1156 Feature #1156

#2390 Feature #2390

#738 Feature 738

#887 Feature #887

#1852 Feature #1852

#2704 Feature #2704

#733 Feature #733

#1369 Feature #1369

#2244 Feature #2244

#1113 Feature #1113

#1794 Feature #1794

#1025 Feature #1025

#2349 Feature #2349

#430 Feature #430

#2384 Feature #2384

#1542 Feature #1542

#113 Feature #113

#819 Feature #819

#905 Feature #905

#2635 Feature #2635

#2524 Feature #2524

#1052 Feature #1052

#1345 Feature #1345

#2678 Feature #2678

#1398 Feature #1398

#1950 Feature #1950

#179 Feature #179

#2637 Feature #2637

#1408 Feature #1408

#2675 Feature #2675

#68 Feature #68

#1285 Feature #1285

#951 Feature #951

#1263 Feature #1263

#1861 Feature #1861

#693 Feature #693

#1879 Feature #1879

#868 Feature #868

#2393 Feature #2393

#1634 Feature #1634

#1536 Feature #1536

#3059 Feature #3059

#1560 Feature #1560

#1730 Feature #1730

#1992 Feature #1992

#1086 Feature #1086

#2336 Feature #2336

#2410 Feature #2410

#2561 Feature #2561

#2651 Feature #2651

#1385 Feature #1385

#1903 Feature #1903

#1530 Feature #1530

#2503 Feature #2503

#271 Feature #271

#1747 Feature #1747

#1353 Feature #1353

#2829 Feature #2829

#2041 Feature #2041

#2264 Feature #2264

#1144 Feature #1144

#1422 Feature #1422

#2530 Feature #2530

#967 Feature #967

#2304 Feature #2304

#583 Feature #583

#159 Feature #159

#2040 Feature #2040

#302 Feature #302

#1828 Feature #1828

#1116 Feature #1116

#1961 Feature #1961

#1660 Feature #1660

#1072 Feature #1072

#937 Feature #937

#662 Feature #662

#1538 Feature #1538

#2318 Feature #2318

#2243 Feature #2243

#1588 Feature #1588

#781 Feature #781

#2529 Feature #2529

#2714 Feature #2714

#2672 Feature #2672

#2255 Feature #2255

#1068 Feature #1068

#973 Feature #973

#932 Feature #932

#2738 Feature #2738

#590 Feature #590

#2925 Feature #2925

#183 Feature #183

#1348 Feature #1348

#1162 Feature #1162

#2085 Feature #2085

#2374 Feature #2374

#1012 Feature #1012

#2284 Feature #2284

#1518 Feature #1518

#806 Feature #806

#1649 Feature #1649

#1339 Feature #1339

#1632 Feature #1632

#915 Feature #915

#653 Feature #653

#2671 Feature #2671

#1231 Feature #1231

#2703 Feature #2703

#135 Feature #135

#2176 Feature #2176

#2263 Feature #2263

#2779 Feature #2779

#2491 Feature #2491

#607 Feature #607

#338 Feature #338

#2257 Feature #2257

#1115 Feature 1115

#53 Feature #53

#792 Feature #792

#2528 Feature #2528

#849 Feature #849

#1859 Feature #1859

#1105 Feature #1105

#2332 Feature #2332

#2963 Feature #2963

#93 Feature #93

#616 Feature #616

#2847 Feature #2847

#2022 Feature #2022

#1181 Feature #1181

#1866 Feature #1866

#42 Feature #42

#2216 Feature #2216

#2777 Feature #2777

#2987 Feature #2987

#1820 Feature #1820

#1383 Feature #1383

#861 Feature #861

#336 Feature #336

#283 Feature #283

#2802 Feature #2802

#1921 Feature #1921

#2969 Feature #2969

#3055 Feature #3055

#276 Feature #276

#2872 Feature #2872

#1179 Feature #1179

#131 Feature 131

#1513 Feature #1513

#1793 Feature #1793

#1056 Feature #1056

#2680 Feature #2680

#801 Feature #801

#1642 Feature #1642

#2907 Feature #2907

#917 Feature #917

#766 Feature #766

#1118 Feature #1118

#279 Feature #279

#636 Feature #636

#2911 Feature #2911

#1784 Feature #1784

#1755 Feature #1755

#2286 Feature #2286

#2863 Feature #2863

#284 Feature #284

#1392 Feature #1392

#1213 Feature 1213

#589 Feature #589

#2668 Feature #2668

#1219 Feature #1219

#2507 Feature #2507

#1578 Feature #1578

#167 Feature #167

#1094 Feature #1094

#1279 Feature 1279

#941 Feature #941

#2351 Feature #2351

#69 Feature #69

#2560 Feature #2560

#1229 Feature #1229

#1954 Feature #1954

#2683 Feature #2683

#337 Feature #337

#2159 Feature #2159

#1322 Feature #1322

#1864 Feature #1864

#2440 Feature #2440

#2415 Feature #2415

#1545 Feature #1545

#249 Feature #249

#1887 Feature #1887

#2397 Feature #2397

#969 Feature #969

#2716 Feature #2716

#1016 Feature #1016

#270 Feature #270

#1042 Feature #1042

#853 Feature #853

#1446 Feature #1446

#1701 Feature #1701

#2323 Feature #2323

#581 Feature #581

#480 Feature #480

#1713 Feature #1713

#497 Feature #497

#266 Feature #266

#1540 Feature #1540

#1604 Feature #1604

#2489 Feature #2489

#1993 Feature #1993

#2174 Feature #2174

#2394 Feature #2394

#350 Feature #350

#1474 Feature #1474

#3000 Feature #3000

#330 Feature #330

#1077 Feature #1077

#681 Feature #681

#1952 Feature #1952

#2828 Feature #2828

#639 Feature #639

#1167 Feature #1167

#314 Feature #314

#1869 Feature #1869

#1100 Feature #1100

#2095 Feature #2095

#2991 Feature #2991

#2460 Feature #2460

#2245 Feature #2245

#238 Feature #238

#1119 Feature #1119

#305 Feature #305

#679 Feature #679

#2534 Feature #2534

#1207 Feature #1207

#2702 Feature #2702

#867 Feature #867

#210 Feature #210

#2976 Feature #2976

#1473 Feature #1473

#1636 Feature #1636

#83 Feature #83

#27 Feature #27

#725 Feature #725

#1837 Feature #1837

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#2429 Feature #2429

#1897 Feature #1897

#2403 Feature #2403

#644 Feature #644

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#2755 Feature #2755

#296 Feature #296

#1589 Feature #1589

#1319 Feature #1319

#2292 Feature 2292

#873 Feature #873

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#928 Feature #928

#220 Feature #220

#1177 Feature #1177

#518 Feature #518

#1639 Feature #1639

#997 Feature #997

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#1615 Feature #1615

#2069 Feature #2069

#1028 Feature #1028

#2865 Feature #2865

#1104 Feature #1104

#2128 Feature #2128

#1493 Feature #1493

#1711 Feature #1711

#116 Feature #116

#1972 Feature 1972

#150 Feature #150

#2624 Feature #2624

#2673 Feature #2673

#1271 Feature #1271

#1716 Feature #1716

#1248 Feature #1248

#759 Feature #759

#2132 Feature #2132

#1687 Feature #1687

#2935 Feature #2935

#417 Feature #417

#273 Feature #273

#2329 Feature #2329

#974 Feature #974

#492 Feature #492

#775 Feature #775

#2827 Feature #2827

#1090 Feature #1090

#101 Feature #101

#2130 Feature #2130

#898 Feature #898

#2111 Feature #2111

#1412 Feature #1412

#1363 Feature #1363

#2371 Feature #2371

#705 Feature #705

#2901 Feature #2901

#1466 Feature #1466

#1227 Feature #1227

#1195 Feature #1195

#550 Feature #550

#2885 Feature #2885

#1508 Feature #1508

#558 Feature #558

#2148 Feature #2148

#2546 Feature #2546

#2199 Feature #2199

#2786 Feature #2786

#2447 Feature #2447

#2520 Feature #2520

#2904 Feature #2904

#2293 Feature #2293

#2785 Feature #2785

#1585 Feature #1585

#218 Feature #218

#1911 Feature #1911

#304 Feature #304

#2375 Feature #2375

#133 Feature #133

#356 Feature #356

#1909 Feature #1909

#1073 Feature #1073

#929 Feature #929

#487 Feature #487

#2299 Feature #2299

#2747 Feature #2747

#244 Feature #244

#2919 Feature #2919

#2205 Feature #2205

#2068 Feature #2068

#696 Feature #696

#2433 Feature 2433

#2004 Feature #2004

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#2072 Feature #2072

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#1572 Feature #1572

#2062 Feature #2062

#1500 Feature #1500

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#1551 Feature #1551

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#265 Feature #265

#2190 Feature #2190

#3068 Feature #3068

#1131 Feature #1131

#317 Feature #317

#1180 Feature #1180

#1204 Feature #1204

#1403 Feature #1403

#162 Feature #162

#2262 Feature #2262

#715 Feature #715

#168 Feature #168

#686 Feature #686

#2074 Feature #2074

#1611 Feature #1611

#985 Feature #985

#2783 Feature #2783

#2708 Feature #2708

#380 Feature #380

#675 Feature #675

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#1956 Feature #1956

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#812 Feature #812

#833 Feature #833

#1303 Feature #1303

#2133 Feature #2133

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#2152 Feature #2152

#2897 Feature #2897

#2439 Feature #2439

#1669 Feature #1669

#2395 Feature #2395

#1829 Feature #1829

#567 Feature #567

#774 Feature #774

#48 Feature #48

#668 Feature #668

#208 Feature #208

#2857 Feature #2857

#1091 Feature #1091

#991 Feature #991

#2089 Feature 2089

#490 Feature #490

#2654 Feature #2654

#1000 Feature #1000

#2527 Feature #2527

#2387 Feature #2387

#728 Feature #728

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#1436 Feature #1436

#416 Feature #416

#1103 Feature #1103

#1243 Feature #1243

#1186 Feature #1186

#1484 Feature #1484

#1888 Feature #1888

#90 Feature #90

#670 Feature #670

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#2225 Feature #2225

#756 Feature #756

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#2021 Feature #2021

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#119 Feature #119

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#2135 Feature #2135

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#10 Feature #10

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#2869 Feature #2869

#1269 Feature #1269

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#2012 Feature #2012

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#221 Feature #221

#2032 Feature #2032

#2873 Feature #2873

#2121 Feature #2121

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#2187 Feature #2187

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#282 Feature #282

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#626 Feature #626

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#780 Feature #780

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#1576 Feature #1576

#1925 Feature #1925

#384 Feature #384

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#1255 Feature #1255

#3036 Feature #3036

#2468 Feature #2468

#2086 Feature #2086

#1237 Feature #1237

#2774 Feature #2774

#912 Feature #912

#643 Feature #643

#983 Feature #983

#716 Feature #716

#2877 Feature #2877

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#2669 Feature #2669

#1301 Feature #1301

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#2142 Feature #2142

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#1739 Feature #1739

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#566 Feature #566

#2381 Feature #2381

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#874 Feature #874

#1533 Feature #1533

#527 Feature #527

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#1813 Feature #1813

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#1569 Feature #1569

#556 Feature #556

#434 Feature #434

#1252 Feature #1252

#181 Feature #181

#1968 Feature #1968

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#2824 Feature #2824

#857 Feature #857

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#2427 Feature #2427

#901 Feature #901

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#1305 Feature #1305

#2169 Feature #2169

#2003 Feature #2003

#74 Feature #74

#1791 Feature #1791

#1433 Feature #1433

#2967 Feature #2967

#1690 Feature #1690

#2378 Feature #2378

#2229 Feature #2229

#1432 Feature #1432

#2649 Feature #2649

#1310 Feature #1310

#2498 Feature #2498

#1238 Feature #1238

#1478 Feature #1478

#2417 Feature #2417

#1074 Feature #1074

#1080 Feature #1080

#2750 Feature #2750

#86 Feature #86

#1573 Feature #1573

#2720 Feature #2720

#517 Feature #517

#1423 Feature #1423

#2423 Feature #2423

#1230 Feature #1230

#1366 Feature #1366

#1885 Feature #1885

#1098 Feature #1098

#2352 Feature #2352

#2141 Feature #2141

#203 Feature #203

#404 Interactions and Mechanisms

#2958 Feature #2958

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Document Content

2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines.
Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring and the nature of the C2-aminoaryl ring. Further lead optimization of the C2-aminoaryl group led to benzoxazepine analogs whose pharmaceutical properties were modulated by the nature of the substituent on the benzoxazepine nitrogen. Tumor stasis (with partial regressions) were observed when an orally bioavailable analog was evaluated in a GTL-16 tumor xenograft mouse model. Subsequent PK/PD studies suggested that a metabolite contributed to the overall in vivo response.

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