Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1483

MIN ACTIVATION

0.0

Details List

#405 Feature 405

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#1792 Metastatic Cancer

#708 Drug Resistance Mechanisms in Cancer

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#1589 Feature 1589

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#3070 Spiritual and Holistic Care in Healthcare

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#2041 Feature 2041

#2385 Feature 2385

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#1302 Sensing and Detection Technologies

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#579 Feature 579

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#2018 Feature 2018

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#1646 Feature 1646

#23 Neuronal Circuitry and Cellular Processes

#409 Feature 409

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#1506 Justification/Rationale for Actions

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#2232 Medical Case Reports & Cancer Research

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#2161 Medical/Scientific Discourse with Ethical/Social Implications

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Document Content

Microfluidic flow fractionation device for label-free isolation of circulating tumor cells (CTCs) from breast cancer patients.
Circulating tumor cells (CTCs) are dissociated from primary tumor and circulate in peripheral blood. They are regarded as the genesis of metastasis. Isolation and enumeration of CTCs serve as valuable tools for cancer prognosis and diagnosis. However, the rarity and heterogeneity of CTCs in blood makes it difficult to separate intact CTCs without loss. In this paper, we introduce a parallel multi-orifice flow fractionation (p-MOFF) device in which a series of contraction/expansion microchannels are placed parallel on a chip forming four identical channels. CTCs were continuously isolated from the whole blood of breast cancer patients by hydrodynamic forces and cell size differences. Blood samples from 24 breast cancer patients were analyzed (half were from metastatic breast cancer patients and the rest were from adjuvant breast cancer patients). The number of isolated CTCs varied from 0 to 21 in 7.5 ml of blood. Because our devices do not require any labeling processes (e.g., EpCAM antibody), heterogeneous CTCs can be isolated regardless of EpCAM expression.

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