Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1473

MIN ACTIVATION

0.0

Details List

#708 Drug Resistance Mechanisms in Cancer

#2467 Feature #2467

#437 Feature #437

#2033 Feature #2033

#1425 Feature 1425

#84 Feature #84

#389 Feature 389

#1805 Feature #1805

#2790 Feature #2790

#1834 Feature #1834

#463 Feature #463

#698 Feature #698

#672 Feature #672

#2309 Feature #2309

#2848 Feature #2848

#2460 Feature #2460

#1028 Feature #1028

#31 Feature #31

#1229 Feature #1229

#2481 Feature #2481

#436 Feature #436

#2803 Feature #2803

#1404 Feature #1404

#548 Feature #548

#405 Feature #405

#1994 Feature #1994

#746 Feature #746

#868 Feature #868

#1578 Feature #1578

#641 Feature #641

#1695 Feature #1695

#2090 Feature #2090

#1492 Feature #1492

#639 Feature #639

#1346 Feature #1346

#2758 Feature #2758

#838 Feature #838

#2677 Feature #2677

#979 Feature #979

#2608 Feature #2608

#2599 Feature #2599

#218 Feature #218

#2555 Feature 2555

#1205 Feature #1205

#1570 Feature #1570

#627 Feature #627

#1793 Feature #1793

#144 Feature #144

#2221 Feature #2221

#2671 Feature #2671

#1604 Feature #1604

#3060 Feature #3060

#1526 Feature #1526

#1548 Feature #1548

#515 Feature #515

#1179 Feature #1179

#997 Feature #997

#112 Feature #112

#38 Feature #38

#1328 Feature #1328

#1458 Feature #1458

#2997 Feature #2997

#1677 Feature #1677

#2992 Feature #2992

#2696 Feature #2696

#2132 Feature #2132

#941 Feature #941

#2213 Feature #2213

#1452 Feature #1452

#1304 Feature #1304

#2414 Feature #2414

#1388 Feature #1388

#2887 Feature #2887

#1844 Feature #1844

#34 Feature #34

#2399 Feature #2399

#2598 Feature #2598

#2792 Feature #2792

#1087 Feature #1087

#1216 Feature #1216

#2753 Feature #2753

#2870 Feature #2870

#1572 Feature #1572

#740 Feature #740

#268 Feature #268

#2766 Feature #2766

#1852 Feature #1852

#1956 Feature #1956

#2025 Feature #2025

#1431 Feature #1431

#2909 Feature #2909

#2740 Feature #2740

#1085 Feature #1085

#2083 Feature #2083

#2082 Feature #2082

#2657 Feature #2657

#932 Feature #932

#253 Feature #253

#2623 Feature #2623

#1317 Feature #1317

#2408 Feature #2408

#778 Feature #778

#2354 Feature #2354

#1209 Feature #1209

#1214 Feature #1214

#222 Feature #222

#2524 Feature #2524

#2903 Feature #2903

#2440 Feature #2440

#476 Feature #476

#2163 Feature #2163

#2340 Feature #2340

#1755 Feature #1755

#3007 Feature #3007

#2761 Feature #2761

#1337 Feature #1337

#2682 Feature 2682

#2070 Feature #2070

#1422 Feature #1422

#1203 Feature #1203

#2560 Feature #2560

#2949 Feature #2949

#2304 Feature #2304

#1545 Feature #1545

#1719 Feature #1719

#2191 Feature #2191

#892 Feature #892

#1873 Feature #1873

#3011 Feature #3011

#2160 Feature #2160

#2732 Feature #2732

#876 Feature #876

#26 Feature #26

#2976 Feature #2976

#449 Feature #449

#190 Feature #190

#1828 Feature #1828

#1941 Feature #1941

#152 Feature #152

#3028 Feature #3028

#2280 Feature #2280

#2592 Feature #2592

#923 Feature #923

#316 Feature #316

#1099 Feature #1099

#2540 Feature #2540

#2561 Feature #2561

#2575 Feature #2575

#350 Feature #350

#2530 Feature #2530

#361 Feature #361

#79 Feature #79

#2138 Feature #2138

#1582 Feature #1582

#2797 Feature #2797

#2869 Feature #2869

#2381 Feature #2381

#964 Feature #964

#1514 Feature #1514

#2427 Feature #2427

#177 Feature #177

#91 Feature #91

#584 Feature #584

#2585 Feature #2585

#1386 Feature #1386

#909 Feature #909

#1976 Feature #1976

#2717 Feature #2717

#547 Feature #547

#1508 Feature #1508

#934 Feature #934

#569 Feature #569

#1946 Feature #1946

#2419 Feature #2419

#2007 Developmental Disparities & Intervention

#1441 Feature #1441

#50 Feature #50

#578 Feature #578

#1262 Feature #1262

#1483 Feature #1483

#723 Feature #723

#1198 Feature #1198

#2600 Feature #2600

#1054 Feature #1054

#1007 Feature #1007

#1869 Feature #1869

#1245 Feature #1245

#1859 Feature #1859

#1586 Feature #1586

#2702 Feature #2702

#1038 Feature #1038

#2806 Feature #2806

#2665 Feature #2665

#1901 Feature #1901

#1456 Feature #1456

#1238 Feature #1238

#766 Feature #766

#1114 Feature #1114

#1652 Feature #1652

#1447 Feature #1447

#1551 Feature #1551

#898 Feature #898

#2495 Feature #2495

#1949 Feature #1949

#1758 Feature #1758

#1097 Feature #1097

#1990 Feature #1990

#973 Feature #973

#251 Feature #251

#1167 Feature #1167

#1669 Feature #1669

#541 Feature #541

#2977 Feature #2977

#219 Feature #219

#158 Feature #158

#370 Feature #370

#555 Feature #555

#1039 Feature #1039

#16 Feature #16

#2822 Feature #2822

#1965 Feature #1965

#1625 Feature #1625

#302 Feature #302

#2980 Feature #2980

#1588 Feature #1588

#579 Feature #579

#1494 Feature #1494

#30 Feature #30

#254 Feature #254

#2497 Feature #2497

#2006 Feature #2006

#559 Feature #559

#1243 Feature #1243

#1279 Feature 1279

#1365 Feature #1365

#274 Feature 274

#411 Feature #411

#1125 Feature #1125

#636 Feature #636

#1983 Feature #1983

#2473 Feature #2473

#2229 Feature #2229

#2368 Feature #2368

#3015 Feature #3015

#2916 Feature 2916

#2963 Feature #2963

#1596 Feature #1596

#1691 Feature #1691

#1606 Feature #1606

#150 Feature #150

#1504 Feature #1504

#1175 Feature #1175

#2931 Feature #2931

#2410 Feature #2410

#2088 Feature #2088

#2320 Feature #2320

#2755 Feature #2755

#283 Feature #283

#524 Feature #524

#2802 Feature #2802

#558 Feature #558

#2533 Feature #2533

#1418 Feature #1418

#64 Feature #64

#2265 Feature #2265

#1896 Feature #1896

#188 Feature #188

#2858 Feature #2858

#2270 Feature #2270

#673 Feature #673

#435 Feature #435

#363 Feature #363

#2108 Feature #2108

#2348 Feature #2348

#2030 Feature #2030

#127 Feature #127

#53 Feature #53

#2199 Feature #2199

#2382 Feature #2382

#612 Feature #612

#172 Feature #172

#198 Feature #198

#2531 Feature #2531

#1903 Feature #1903

#114 Feature #114

#1628 Feature #1628

#2863 Feature #2863

#693 Feature #693

#687 Feature #687

#2908 Feature #2908

#2868 Feature #2868

#625 Feature #625

#340 Feature #340

#1753 Feature #1753

#1084 Feature #1084

#2416 Feature #2416

#630 Feature #630

#1348 Feature #1348

#1319 Feature #1319

#1144 Feature #1144

#1082 Feature #1082

#811 Feature #811

#427 Feature #427

#1699 Feature #1699

#2184 Feature #2184

#1398 Feature #1398

#2589 Feature #2589

#648 Feature #648

#1195 Feature #1195

#2954 Feature #2954

#618 Feature #618

#227 Feature #227

#3063 Feature #3063

#2394 Feature #2394

#557 Feature #557

#609 Feature #609

#1116 Feature #1116

#1244 Feature #1244

#1964 Feature #1964

#1017 Feature #1017

#1867 Feature #1867

#205 Feature #205

#2987 Feature #2987

#1293 Feature #1293

#295 Feature #295

#1516 Feature #1516

#1307 Feature #1307

#70 Feature #70

#413 Feature #413

#2527 Feature #2527

#2069 Feature #2069

#2485 Feature #2485

#2874 Feature #2874

#1660 Feature #1660

#2733 Feature #2733

#3001 Feature #3001

#179 Feature #179

#2291 Feature #2291

#2917 Feature #2917

#2255 Feature #2255

#495 Feature #495

#2813 Feature #2813

#2487 Feature #2487

#615 Feature #615

#1080 Feature #1080

#2086 Feature #2086

#1912 Feature #1912

#1025 Feature #1025

#1797 Feature #1797

#2104 Feature #2104

#482 Feature #482

#1351 Feature #1351

#2081 Feature #2081

#2097 Feature #2097

#390 Feature #390

#2261 Feature #2261

#49 Feature #49

#887 Feature #887

#422 Feature #422

#2553 Feature #2553

#1927 Feature #1927

#14 Feature #14

#856 Feature #856

#1887 Feature #1887

#1049 Feature #1049

#1919 Feature #1919

#1402 Feature #1402

#1052 Feature #1052

#2611 Feature #2611

#2300 Feature #2300

#563 Feature #563

#2292 Feature 2292

#653 Feature #653

#761 Feature #761

#90 Feature #90

#960 Feature #960

#600 Feature #600

#2350 Feature #2350

#2113 Feature #2113

#2151 Feature #2151

#1360 Feature #1360

#1215 Feature #1215

#2417 Feature #2417

#1537 Feature #1537

#1142 Feature #1142

#1273 Feature #1273

#397 Feature #397

#695 Feature #695

#3066 Feature #3066

#334 Feature #334

#128 Feature #128

#1853 Feature #1853

#733 Feature #733

#792 Feature #792

#696 Feature #696

#2662 Feature #2662

#860 Feature #860

#215 Feature #215

#1879 Feature #1879

#42 Feature #42

#882 Feature #882

#2966 Feature #2966

#2957 Feature #2957

#1487 Feature #1487

#879 Feature #879

#231 Feature #231

#1016 Feature #1016

#1126 Feature #1126

#1192 Feature #1192

#1470 Feature #1470

#729 Feature #729

#107 Feature #107

#739 Feature #739

#1683 Feature #1683

#2757 Feature #2757

#1763 Feature #1763

#279 Feature #279

#3059 Feature #3059

#574 Feature #574

#325 Feature #325

#1929 Feature #1929

#337 Feature #337

#1124 Feature #1124

#583 Feature #583

#2227 Feature #2227

#2789 Feature #2789

#2242 Feature #2242

#2849 Feature #2849

#2374 Feature #2374

#1254 Feature #1254

#394 Feature #394

#187 Feature #187

#2490 Feature #2490

#802 Feature #802

#2333 Feature #2333

#2881 Feature #2881

#2461 Feature #2461

#1130 Feature #1130

#667 Feature #667

#791 Feature #791

#712 Feature #712

#1712 Feature #1712

#1503 Feature #1503

#196 Feature #196

#1796 Feature #1796

#1542 Feature #1542

#958 Feature #958

#2723 Feature #2723

#1777 Feature #1777

#2010 Feature #2010

#2197 Feature #2197

#360 Feature #360

#1043 Feature #1043

#776 Feature #776

#572 Feature #572

#168 Feature #168

#2667 Feature #2667

#1412 Feature #1412

#1399 Feature #1399

#738 Feature 738

#990 Feature #990

#402 Feature #402

#1870 Feature #1870

#1424 Feature #1424

#1187 Feature #1187

#2507 Feature #2507

#1414 Feature #1414

#1139 Feature #1139

#1068 Feature #1068

#565 Feature #565

#1185 Feature #1185

#1467 Feature #1467

#111 Feature #111

#1520 Feature #1520

#249 Feature #249

#2519 Feature #2519

#1286 Feature #1286

#1358 Feature #1358

#2612 Feature #2612

#2188 Feature #2188

#1475 Feature #1475

#260 Feature #260

#307 Feature #307

#983 Feature #983

#780 Feature #780

#655 Feature #655

#1011 Feature #1011

#3026 Feature #3026

#2462 Feature #2462

#3021 Feature #3021

#1880 Feature #1880

#2864 Feature #2864

#1420 Feature #1420

#2738 Feature #2738

#3049 Feature #3049

#417 Feature #417

#2973 Feature #2973

#2676 Feature #2676

#1166 Feature #1166

#1318 Feature #1318

#894 Feature #894

#2004 Feature #2004

#186 Feature #186

#1816 Feature #1816

#2684 Feature #2684

#2785 Feature #2785

#2686 Feature #2686

#1829 Feature #1829

#2962 Feature #2962

#2284 Feature #2284

#1954 Feature #1954

#1560 Feature #1560

#1643 Feature #1643

#759 Feature #759

#1766 Feature #1766

#3006 Feature #3006

#2593 Feature #2593

#896 Feature #896

#2669 Feature #2669

#113 Feature #113

#2039 Feature #2039

#1973 Feature #1973

#525 Feature #525

#1105 Feature #1105

#568 Feature #568

#2520 Feature #2520

#1785 Feature #1785

#2516 Feature #2516

#1972 Feature 1972

#2910 Feature #2910

#949 Feature #949

#108 Feature #108

#2013 Feature #2013

#1476 Feature #1476

#3009 Feature #3009

#556 Feature #556

#2241 Feature #2241

#640 Feature #640

#581 Feature #581

#357 Feature #357

#1263 Feature #1263

#2406 Feature #2406

#967 Feature #967

#2649 Feature #2649

#874 Feature #874

#944 Feature #944

#329 Feature #329

#1738 Feature #1738

#2703 Feature #2703

#1700 Feature #1700

#1889 Feature #1889

#987 Feature #987

#261 Feature 261

#1315 Feature #1315

#2452 Feature #2452

#858 Feature #858

#580 Feature #580

#1020 Feature #1020

#772 Feature #772

#2503 Feature #2503

#225 Feature #225

#410 Feature #410

#309 Feature #309

#1960 Feature #1960

#1837 Feature #1837

#2174 Feature #2174

#1920 Feature #1920

#1624 Feature #1624

#1868 Feature #1868

#352 Feature #352

#2062 Feature #2062

#1519 Feature #1519

#1066 Feature #1066

#2387 Feature #2387

#1786 Feature #1786

#757 Feature #757

#2907 Feature #2907

#2847 Feature #2847

#826 Feature #826

#2483 Feature #2483

#500 Feature #500

#451 Feature #451

#2846 Feature #2846

#1158 Feature #1158

#2551 Feature #2551

#537 Feature #537

#3010 Feature #3010

#1339 Feature #1339

#1178 Feature #1178

#754 Feature #754

#1800 Feature #1800

#529 Feature #529

#1248 Feature #1248

#1186 Feature #1186

#1851 Feature #1851

#45 Feature #45

#2750 Feature #2750

#2905 Feature #2905

#2441 Feature #2441

#1024 Feature #1024

#1497 Feature #1497

#1762 Feature #1762

#33 Feature #33

#1067 Feature #1067

#812 Feature #812

#899 Feature #899

#1631 Feature #1631

#1549 Feature #1549

#1449 Feature #1449

#2678 Feature #2678

#3065 Feature #3065

#633 Feature #633

#783 Feature #783

#2355 Feature #2355

#657 Feature #657

#2101 Feature #2101

#2709 Feature #2709

#74 Feature #74

#1773 Feature #1773

#323 Feature #323

#1217 Feature #1217

#845 Feature #845

#582 Feature #582

#2353 Feature #2353

#240 Feature #240

#1530 Feature #1530

#1749 Feature #1749

#2146 Feature #2146

#1196 Feature #1196

#2424 Feature #2424

#1546 Feature #1546

#1645 Feature #1645

#265 Feature #265

#2573 Feature #2573

#849 Feature #849

#1948 Feature #1948

#2628 Feature #2628

#1696 Feature #1696

#2884 Feature #2884

#1197 Feature #1197

#2749 Feature #2749

#2809 Feature #2809

#2965 Feature #2965

#948 Feature #948

#841 Feature #841

#1607 Feature #1607

#2206 Feature #2206

#399 Feature #399

#861 Feature #861

#554 Feature #554

#2026 Feature #2026

#403 Feature #403

#317 Feature #317

#873 Feature #873

#1311 Molecular Mechanisms and Biological Processes

#597 Feature #597

#1378 Feature #1378

#2250 Feature 2250

#2119 Feature #2119

#1484 Feature #1484

#511 Feature #511

#1369 Feature #1369

#911 Feature #911

#508 Feature #508

#1569 Feature #1569

#2591 Feature #2591

#2955 Feature #2955

#2994 Feature #2994

#1445 Feature #1445

#430 Feature #430

#637 Feature #637

#2397 Feature #2397

#2323 Feature #2323

#1620 Feature #1620

#2198 Feature #2198

#2841 Feature #2841

#1350 Feature #1350

#1493 Feature #1493

#1269 Feature #1269

#1407 Feature #1407

#235 Feature #235

#2288 Feature #2288

#886 Feature #886

#1234 Feature #1234

#2946 Feature #2946

#2305 Feature 2305

#1909 Feature #1909

#1193 Feature #1193

#1813 Feature #1813

#1757 Feature #1757

#577 Feature #577

#621 Feature #621

#1584 Feature #1584

#1231 Feature #1231

#1344 Feature #1344

#966 Feature #966

#1077 Feature #1077

#233 Feature #233

#2469 Feature #2469

#2337 Feature #2337

#1882 Feature #1882

#3037 Feature #3037

#1657 Feature #1657

#505 Feature #505

#2783 Feature #2783

#980 Feature #980

#1917 Feature #1917

#2795 Feature #2795

#2475 Feature #2475

#477 Feature #477

#25 Feature #25

#2055 Feature #2055

#46 Feature #46

#897 Feature #897

#1177 Feature #1177

#1469 Feature #1469

#2805 Feature #2805

#2833 Feature #2833

#237 Feature #237

#2637 Feature #2637

#1713 Feature #1713

#518 Feature #518

#1676 Feature #1676

#2415 Feature #2415

#1926 Feature #1926

#241 Feature #241

#497 Feature #497

#1565 Feature #1565

#1518 Feature #1518

#2205 Feature #2205

#1590 Feature #1590

#1131 Feature #1131

#1993 Feature #1993

#488 Feature #488

#313 Feature #313

#715 Feature #715

#1042 Feature #1042

#553 Feature #553

#668 Feature #668

#2130 Feature #2130

#517 Feature #517

#1633 Feature #1633

#2856 Feature #2856

#115 Feature #115

#2302 Feature #2302

#66 Feature #66

#2298 Feature #2298

#2626 Feature #2626

#1772 Feature #1772

#2027 Feature #2027

#2767 Feature #2767

#1200 Feature #1200

#2331 Feature #2331

#1748 Feature #1748

#2107 Feature #2107

#1967 Feature #1967

#651 Feature #651

#829 Feature #829

#2613 Feature #2613

#1512 Feature #1512

#1240 Feature #1240

#1356 Feature 1356

#1359 Feature #1359

#771 Feature #771

#1910 Feature #1910

#368 Feature #368

#1992 Feature #1992

#2073 Feature #2073

#162 Feature #162

#1041 Feature #1041

#1063 Feature #1063

#3032 Feature #3032

#1148 Feature #1148

#562 Feature #562

#1460 Feature #1460

#1119 Feature #1119

#2401 Feature #2401

#315 Feature #315

#1436 Feature #1436

#890 Feature #890

#2535 Feature #2535

#185 Feature #185

#1654 Feature #1654

#872 Feature #872

#2583 Feature #2583

#2372 Feature #2372

#2351 Feature #2351

#1343 Feature #1343

#109 Feature #109

#3002 Feature #3002

#1594 Feature #1594

#2203 Feature #2203

#1680 Feature #1680

#2023 Feature #2023

#380 Feature #380

#1778 Feature #1778

#2552 Feature #2552

#516 Feature #516

#846 Feature #846

#844 Feature #844

#3061 Feature #3061

#2731 Feature #2731

#2237 Feature #2237

#374 Medical Imaging and Oncology

#965 Feature #965

#1616 Feature #1616

#847 Feature #847

#1694 Feature #1694

#2940 Feature #2940

#662 Feature #662

#138 Feature #138

#3016 Feature #3016

#1297 Feature #1297

#1979 Feature #1979

#2701 Feature 2701

#2556 Feature #2556

#1308 Feature #1308

#2602 Feature #2602

#1266 Feature #1266

#1509 Feature #1509

#1671 Feature #1671

#803 Feature #803

#1863 Feature #1863

#1776 Feature #1776

#2510 Feature #2510

#1843 Feature #1843

#2215 Feature #2215

#1065 Feature #1065

#2216 Feature #2216

#3035 Feature #3035

#805 Feature #805

#1157 Feature #1157

#1692 Feature #1692

#950 Feature #950

#576 Feature #576

#875 Feature #875

#2947 Feature #2947

#816 Feature #816

#1323 Feature #1323

#1720 Feature #1720

#2230 Feature #2230

#189 Feature #189

#247 Feature #247

#2254 Feature #2254

#2208 Feature #2208

#588 Feature #588

#2548 Feature #2548

#1818 Feature #1818

#502 Feature #502

#2672 Feature #2672

#2716 Feature #2716

#2369 Feature #2369

#642 Feature #642

#1953 Feature #1953

#2668 Feature #2668

#1383 Feature #1383

#2245 Feature #2245

#770 Feature #770

#2622 Feature #2622

#2889 Feature #2889

#133 Feature #133

#1640 Feature #1640

#1221 Feature #1221

#2266 Feature #2266

#2147 Feature #2147

#17 Feature #17

#2961 Feature #2961

#1481 Feature #1481

#916 Feature #916

#1610 Feature #1610

#238 Feature #238

#2260 Historical Context & Development

#376 Feature #376

#356 Feature #356

#2296 Feature #2296

#799 Feature #799

#2885 Feature #2885

#1792 Metastatic Cancer

#2877 Feature #2877

#1665 Feature #1665

#922 Feature #922

#1627 Feature 1627

#3048 Feature #3048

#2068 Feature #2068

#853 Feature #853

#1415 Feature #1415

#359 Feature #359

#1911 Feature #1911

#392 Feature #392

#1821 Feature #1821

#1905 Feature #1905

#2861 Feature #2861

#19 Feature #19

#167 Feature #167

#567 Feature #567

#1180 Feature #1180

#1448 Feature #1448

#855 Feature #855

#2389 Feature #2389

#675 Feature #675

#2791 Feature #2791

#2361 Feature #2361

#2158 Feature #2158

#2737 Feature #2737

#2991 Feature #2991

#2782 Feature #2782

#1996 Feature #1996

#1885 Feature #1885

#1169 Feature #1169

#2003 Feature #2003

#300 Feature #300

#527 Feature #527

#2050 Feature #2050

#1000 Feature #1000

#2183 Feature #2183

#1182 Feature #1182

#116 Feature #116

#775 Feature #775

#1501 Feature #1501

#1161 Feature #1161

#2538 Feature #2538

#1237 Feature #1237

#2045 Feature #2045

#478 Feature #478

#3056 Feature #3056

#2577 Feature #2577

#1098 Feature #1098

#836 Feature #836

#1567 Feature #1567

#1743 Feature #1743

#1636 Feature #1636

#48 Feature #48

#689 Feature #689

#1123 Feature #1123

#2633 Feature #2633

#939 Feature #939

#915 Feature #915

#2224 Feature #2224

#1446 Feature #1446

#2185 Feature #2185

#912 Feature #912

#2248 Feature #2248

#2836 Feature #2836

#1121 Feature #1121

#2453 Feature #2453

#136 Feature #136

#2085 Feature #2085

#101 Feature #101

#2901 Feature #2901

#2282 Feature #2282

#1385 Feature #1385

#2219 Feature #2219

#2888 Feature #2888

#2116 Feature #2116

#1734 Feature #1734

#2646 Feature #2646

#1794 Feature #1794

#61 Feature #61

#95 Feature #95

#1061 Feature #1061

#39 Feature #39

#2098 Feature #2098

#143 Feature #143

#409 Feature #409

#272 Feature #272

#2972 Sensory-Motor Integration

#2038 Feature #2038

#2470 Feature #2470

#2967 Feature #2967

#2293 Feature #2293

#2565 Feature #2565

#1784 Feature #1784

#271 Feature #271

#135 Feature #135

#2479 Feature #2479

#2529 Feature #2529

#1819 Feature #1819

#2930 Feature #2930

#971 Feature #971

#2624 Feature #2624

#2271 Feature #2271

#1156 Feature #1156

#1048 Feature #1048

#2067 Feature #2067

#1280 Feature #1280

#1223 Feature #1223

#2438 Feature #2438

#3023 Feature #3023

#2074 Feature #2074

#2168 Feature #2168

#1552 Feature #1552

#3020 Feature #3020

#287 Feature #287

#1893 Feature #1893

#1997 Feature #1997

#1634 Feature #1634

#1236 Feature #1236

#705 Feature #705

#891 Feature #891

#2179 Feature #2179

#2244 Feature #2244

#1037 Feature 1037

#528 Feature #528

#1071 Feature #1071

#2698 Feature #2698

#1199 Feature #1199

#118 Feature #118

#93 Feature #93

#1721 Feature #1721

#1242 Feature #1242

#1421 Feature #1421

#867 Feature #867

#1961 Feature #1961

#2014 Feature #2014

#919 Feature #919

#644 Feature #644

#2658 Feature #2658

#1224 Feature #1224

#1935 Feature #1935

#1952 Feature #1952

#2064 Feature #2064

#2712 Feature #2712

#1623 Feature #1623

#175 Feature #175

#2175 Feature #2175

#1580 Feature #1580

#1760 Feature #1760

#1150 Feature #1150

#1313 Feature #1313

#550 Feature #550

#1902 Feature #1902

#1750 Feature #1750

#319 Feature #319

#2523 Feature #2523

#1005 Feature #1005

#794 Feature #794

#900 Feature #900

#1152 Feature #1152

#1860 Feature #1860

#1595 Feature #1595

#303 Feature #303

#2375 Feature #2375

#1092 Feature #1092

#1722 Feature #1722

#1055 Feature #1055

#749 Feature #749

#1034 Feature #1034

#1824 Feature #1824

#1354 Feature #1354

#1316 Feature #1316

#2563 Feature #2563

#2135 Feature #2135

#1050 Feature #1050

#2743 Feature #2743

#67 Feature #67

#2190 Feature #2190

#832 Feature #832

#594 Feature #594

#938 Feature #938

#1653 Feature #1653

#44 Feature #44

#2209 Feature #2209

#2857 Feature #2857

#955 Feature #955

#1932 Feature #1932

#699 Feature #699

#930 Feature #930

#1849 Feature #1849

#1611 Feature #1611

#2539 Feature #2539

#599 Feature #599

#727 Feature #727

#670 Feature #670

#1032 Feature #1032

#933 Feature #933

#1428 Feature #1428

#3071 Feature #3071

#396 Feature #396

#1006 Feature #1006

#917 Feature #917

#928 Feature #928

#1550 Feature #1550

#2100 Feature #2100

#2035 Feature #2035

#1417 Feature #1417

#124 Feature #124

#496 Feature #496

#1585 Feature #1585

#2391 Feature #2391

#3036 Feature #3036

#2568 Feature #2568

#786 Feature 786

#1831 Feature #1831

#1379 Feature #1379

#1324 Feature #1324

#790 Feature #790

#2880 Feature #2880

#755 Feature #755

#420 Feature #420

#1416 Feature #1416

#1681 Feature #1681

#2463 Feature #2463

#1826 Feature #1826

#2402 Feature #2402

#767 Feature #767

#745 Feature #745

#1094 Feature #1094

#2121 Feature #2121

#1513 Feature #1513

#1598 Feature #1598

#78 Feature #78

#2029 Feature #2029

#1345 Feature #1345

#487 Feature #487

#645 Feature #645

#2826 Feature #2826

#1966 Feature #1966

#2663 Feature #2663

#1495 Feature #1495

#1662 Feature #1662

#1864 Feature #1864

#777 Feature #777

#3012 Feature #3012

#526 Feature #526

#629 Feature #629

#1807 Feature #1807

#1482 Feature #1482

#1615 Feature #1615

#3019 Feature #3019

#2425 Feature #2425

#1440 Feature #1440

#1872 Feature #1872

#1991 Feature #1991

#701 Feature #701

#259 Feature #259

#2936 Feature #2936

#2431 Feature #2431

#3040 Feature #3040

#2651 Feature #2651

#1434 Feature #1434

#725 Feature #725

#2559 Feature #2559

#2562 Feature #2562

#2541 Feature #2541

#768 Feature #768

#2171 Molecular and Cellular Biological Processes

#1781 Feature #1781

#83 Feature #83

#475 Feature #475

#2913 Feature #2913

#2818 Feature #2818

#2845 Feature #2845

#2776 Feature #2776

#195 Feature #195

#372 Feature #372

#1731 Feature #1731

#2283 Feature #2283

#3042 Feature 3042

#1924 Feature #1924

#314 Feature #314

#613 Feature #613

#610 Feature #610

#2099 Feature #2099

#1968 Feature #1968

#2436 Feature #2436

#1661 Feature #1661

#119 Feature #119

#743 Feature #743

#1377 Feature #1377

#2572 Feature #2572

#2549 Feature #2549

#2945 Feature 2945

#1629 Feature #1629

#1015 Feature #1015

#2704 Feature #2704

#416 Feature #416

#1962 Feature #1962

#1740 Feature #1740

#3014 Feature #3014

#1083 Feature #1083

#288 Feature #288

#2772 Feature #2772

#276 Feature #276

#905 Feature #905

#2477 Feature #2477

#2515 Feature #2515

#1589 Feature #1589

#1557 Feature #1557

#2125 Feature #2125

#1845 Feature #1845

#2496 Feature #2496

#1410 Feature #1410

#354 Feature #354

#157 Feature #157

#285 Feature #285

#717 Feature #717

#2459 Feature #2459

#1302 Sensing and Detection Technologies

#200 Feature #200

#976 Feature #976

#1617 Feature #1617

#764 Feature #764

#375 Feature #375

#2134 Feature #2134

#2341 Feature #2341

#1433 Feature #1433

#2582 Feature #2582

#2922 Feature #2922

#2685 Feature #2685

#2942 Feature #2942

#304 Feature #304

#230 Feature #230

#889 Feature #889

#1009 Feature #1009

#1732 Feature #1732

#2456 Feature #2456

#1877 Feature #1877

#2498 Feature #2498

#1208 Feature #1208

#2358 Feature #2358

#1107 Feature #1107

#204 Feature #204

#1888 Feature #1888

#492 Feature #492

#431 Feature #431

#2618 Feature #2618

#1072 Feature #1072

#1739 Feature #1739

#566 Feature #566

#2409 Feature #2409

#441 Feature #441

#2330 Feature #2330

#1127 Feature #1127

#201 Feature #201

#2697 Feature #2697

#1164 Feature #1164

#388 Feature #388

#445 Feature #445

#13 Feature #13

#961 Feature #961

#1650 Feature #1650

#2544 Feature #2544

#1352 Feature #1352

#924 Feature #924

#2660 Feature #2660

#2770 Feature #2770

#2437 Feature #2437

#2681 Feature #2681

#666 Feature #666

#2395 Feature #2395

#286 Feature #286

#1091 Feature #1091

#250 Feature #250

#2318 Feature #2318

#2875 Feature #2875

#2801 Feature #2801

#1312 Feature #1312

#784 Feature #784

#1507 Feature #1507

#2900 Feature #2900

#1737 Feature #1737

#180 Feature #180

#1468 Feature #1468

#1134 Feature #1134

#328 Feature #328

#1856 Feature #1856

#1506 Justification/Rationale for Actions

#968 Feature #968

#353 Feature #353

#1539 Feature #1539

#1988 Feature #1988

#1100 Feature #1100

#824 Feature #824

#1113 Feature #1113

#539 Feature #539

#1815 Feature #1815

#1556 Feature #1556

#1561 Feature #1561

#1004 Feature #1004

#1246 Feature #1246

#456 Feature #456

#1184 Feature #1184

#607 Feature #607

#1325 Feature #1325

#2567 Feature #2567

#1521 Feature #1521

#1079 Feature #1079

#2243 Feature #2243

#290 Feature #290

#535 Feature #535

#665 Feature #665

#1747 Feature #1747

#1716 Feature #1716

#819 Feature #819

#2429 Feature #2429

#963 Feature #963

#2928 Feature #2928

#2778 Hippocampal Memory and Cognitive Function

#1523 Feature #1523

#2201 Feature #2201

#810 Feature #810

#3018 Feature #3018

#289 Feature #289

#1709 Feature #1709

#2076 Feature #2076

#2925 Feature #2925

#2489 Feature #2489

#2727 Feature #2727

#2948 Feature #2948

#1804 Feature #1804

#1883 Feature #1883

#631 Feature #631

#1380 Feature #1380

#1562 Feature #1562

#2837 Feature #2837

#854 Feature #854

#2178 Feature #2178

#466 Feature #466

#1397 Feature #1397

#1675 Feature #1675

#1171 Feature #1171

#1338 Feature #1338

#3055 Feature #3055

#2232 Medical Case Reports & Cancer Research

#1790 Feature #1790

#1835 Feature #1835

#1353 Feature 1353

#3053 Feature #3053

#1571 Feature #1571

#1704 Feature #1704

#1227 Feature #1227

#1332 Feature #1332

#1944 Feature 1944

#1334 Feature #1334

#974 Feature #974

#1820 Feature #1820

#1035 Feature #1035

#1525 Feature #1525

#656 Feature #656

#203 Feature #203

#649 Feature #649

#880 Feature #880

#1320 Feature #1320

#2720 Feature #2720

#2066 Feature #2066

#183 Feature #183

#1847 Feature #1847

#1406 Feature #1406

#744 Feature #744

#32 Feature #32

#1857 Feature #1857

#1496 Feature #1496

#2644 Feature #2644

#2285 Feature #2285

#23 Neuronal Circuitry and Cellular Processes

#2574 Feature #2574

#1466 Feature #1466

#1255 Feature #1255

#1154 Feature #1154

#110 Feature #110

#1253 Feature #1253

#1270 Feature #1270

#956 Feature #956

#344 Feature #344

#678 Feature #678

#1689 Feature #1689

#1394 Feature #1394

#358 Feature #358

#2234 Feature #2234

#1742 Feature #1742

#2700 Feature #2700

#159 Feature #159

#756 Feature #756

#2346 Feature #2346

#294 Feature #294

#2059 Feature #2059

#1971 Feature #1971

#164 Feature 164

#2087 Feature #2087

#506 Feature #506

#2588 Feature #2588

#2259 Feature #2259

#1375 Feature #1375

#2528 Feature #2528

#335 Feature #335

#2986 Feature #2986

#1272 Feature #1272

#1618 Feature #1618

#823 Feature #823

#2512 Feature #2512

#2764 Feature #2764

#2001 Feature #2001

#1511 Feature #1511

#2136 Feature #2136

#1977 Feature #1977

#2377 Feature #2377

#913 Feature #913

#2821 Feature #2821

#2944 Feature #2944

#1540 Feature #1540

#2366 Feature #2366

#2895 Feature #2895

#1165 Feature #1165

#1974 Feature #1974

#2222 Feature #2222

#2041 Feature #2041

#2109 Feature #2109

#2932 Feature #2932

#2596 Feature 2596

#339 Feature #339

#2694 Feature #2694

#1326 Feature #1326

#1423 Feature #1423

#1533 Feature #1533

#2103 Feature #2103

#1212 Feature #1212

#2526 Feature #2526

#1950 Feature #1950

#2233 Feature #2233

#1012 Feature #1012

#1729 Feature #1729

#647 Feature #647

#669 Feature #669

#2722 Feature #2722

#246 Feature #246

#1464 Feature #1464

#801 Feature #801

#2793 Feature #2793

#156 Feature #156

#1711 Feature #1711

#1239 Feature #1239

#407 Feature #407

#493 Feature #493

#758 Feature #758

#160 Feature #160

#310 Feature #310

#1913 Feature #1913

#1630 Feature #1630

#3043 Feature #3043

#617 Feature #617

#171 Feature #171

#2426 Feature #2426

#616 Feature #616

#1809 Feature #1809

#2356 Feature #2356

#145 Feature #145

#1759 Feature #1759

#1768 Feature #1768

#1089 Feature #1089

#1419 Feature #1419

#2674 Feature #2674

#312 Feature #312

#2170 Feature #2170

#223 Feature #223

#1858 Feature #1858

#2835 Feature #2835

#1056 Feature #1056

#991 Feature #991

#139 Feature #139

#2102 Feature #2102

#1046 Feature #1046

#1300 Feature #1300

#1001 Feature #1001

#1181 Feature #1181

#2042 Feature #2042

#1059 Feature #1059

#88 Feature #88

#3003 Feature #3003

#2866 Feature #2866

#2442 Feature #2442

Document Content

Identification and functional signature of genes regulated by structurally different ABL kinase inhibitors.
Dasatinib is an ATP-competitive, multi-targeted SRC and ABL kinase inhibitor that can bind BCR-ABL in both the active and inactive conformations. From a clinical standpoint, dasatinib is particularly attractive because it has been shown to induce hematologic and cytogenetic responses in imatinib-resistant chronic myeloid leukemia patients. The fact because the combination of imatinib and dasatinib shows the additive/synergistic growth inhibition on wild-type p210 BCR-ABL-expressing cells, we reasoned that these ABL kinase inhibitors might induce the different molecular pathways. To address this question, we used DNA microarrays to identify genes whose transcription was altered by imatinib and dasatinib. K562 cells were cultured with imatinib or dasatinib for 16 h, and gene expression data were obtained from three independent microarray hybridizations. Almost all of the imatinib- and dasatinib-responsive genes appeared to be similarly increased or decreased in K562 cells; however, small subsets of genes were identified as selectively altered expression by either imatinib or dasatinib. The distinct genes that are selectively modulated by dasatinib are cyclin-dependent kinase 2 (CDK2) and CDK8, which had a maximal reduction of <5-fold in microarray screen. To assess the functional importance of dasatinib regulated genes, we used RNA interference to determine whether reduction of CDK2 and CDK8 affected the growth inhibition. K562 and TF-1BCR-ABL cells, pretreated with CDK2 or CDK8 small interfering RNA, showed additive growth inhibition with imatinib, but not with dasatinib. These findings demonstrate that the additive/synergistic growth inhibition by imatinib and dasatinib may be mediated in part by CDK2 and CDK8.

Similar Documents