Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1486

MIN ACTIVATION

0.0

Details List

#708 Drug Resistance Mechanisms in Cancer

#672 Feature #672

#1805 Feature #1805

#2803 Feature #2803

#1867 Feature #1867

#2174 Feature #2174

#187 Feature #187

#2790 Feature #2790

#2671 Feature #2671

#2132 Feature #2132

#1896 Feature #1896

#1548 Feature #1548

#1346 Feature #1346

#1028 Feature #1028

#639 Feature #639

#548 Feature #548

#1425 Feature 1425

#2467 Feature #2467

#2460 Feature #2460

#2033 Feature #2033

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#2575 Feature #2575

#2419 Feature #2419

#84 Feature #84

#1365 Feature #1365

#597 Feature #597

#1006 Feature #1006

#1198 Feature #1198

#579 Feature #579

#2291 Feature #2291

#2108 Feature #2108

#436 Feature #436

#876 Feature #876

#1604 Feature #1604

#74 Feature #74

#1245 Feature #1245

#1844 Feature #1844

#2931 Feature #2931

#389 Feature 389

#463 Feature #463

#1130 Feature #1130

#738 Feature 738

#2792 Feature #2792

#627 Feature #627

#766 Feature #766

#641 Feature #641

#2160 Feature #2160

#2340 Feature #2340

#1834 Feature #1834

#218 Feature #218

#2090 Feature #2090

#2758 Feature #2758

#997 Feature #997

#887 Feature #887

#746 Feature #746

#1994 Feature #1994

#2848 Feature #2848

#2086 Feature #2086

#437 Feature #437

#2592 Feature #2592

#1216 Feature #1216

#3060 Feature #3060

#2845 Feature #2845

#1965 Feature #1965

#838 Feature #838

#1695 Feature #1695

#757 Feature #757

#405 Feature #405

#1792 Metastatic Cancer

#979 Feature #979

#1483 Feature #1483

#363 Feature #363

#952 Feature #952

#2916 Feature 2916

#2354 Feature #2354

#990 Feature #990

#64 Feature #64

#2350 Feature #2350

#2309 Feature #2309

#634 Feature #634

#1537 Feature #1537

#3007 Feature #3007

#90 Feature #90

#1487 Feature #1487

#2276 Feature #2276

#960 Feature #960

#2401 Feature #2401

#1167 Feature #1167

#2055 Feature #2055

#93 Feature #93

#1596 Feature #1596

#334 Feature #334

#2070 Feature #2070

#2280 Feature #2280

#740 Feature #740

#1476 Feature #1476

#2250 Feature 2250

#890 Feature #890

#2657 Feature #2657

#934 Feature #934

#987 Feature #987

#698 Feature #698

#38 Feature #38

#967 Feature #967

#1946 Feature #1946

#1949 Feature #1949

#2004 Feature #2004

#1099 Feature #1099

#929 Feature #929

#2138 Feature #2138

#1610 Feature #1610

#1304 Feature #1304

#575 Feature #575

#1753 Feature #1753

#2797 Feature #2797

#2589 Feature #2589

#1486 Feature #1486

#1407 Feature #1407

#941 Feature #941

#2665 Feature #2665

#2013 Feature #2013

#1243 Feature #1243

#2844 Feature #2844

#152 Feature #152

#1420 Feature #1420

#283 Feature #283

#2647 Feature #2647

#815 Feature #815

#1116 Feature #1116

#350 Feature #350

#265 Feature #265

#411 Feature #411

#1404 Feature #1404

#1025 Feature #1025

#31 Feature #31

#673 Feature #673

#1054 Feature #1054

#511 Feature #511

#816 Feature #816

#115 Feature #115

#1441 Feature #1441

#1085 Feature #1085

#1582 Feature #1582

#1492 Feature #1492

#2206 Feature #2206

#2977 Feature #2977

#1556 Feature #1556

#1606 Feature #1606

#1484 Feature #1484

#1203 Feature #1203

#317 Feature #317

#868 Feature #868

#973 Feature #973

#2133 Feature #2133

#34 Feature #34

#2213 Feature #2213

#2738 Feature #2738

#451 Feature #451

#2599 Feature #2599

#422 Feature #422

#379 Feature #379

#2696 Feature #2696

#1262 Feature #1262

#1297 Feature #1297

#1786 Feature #1786

#1967 Feature #1967

#792 Feature #792

#2702 Feature #2702

#375 Feature #375

#550 Feature #550

#1584 Feature #1584

#916 Feature #916

#188 Feature #188

#1386 Feature #1386

#2857 Feature #2857

#227 Feature #227

#1042 Feature #1042

#558 Feature #558

#2525 Feature #2525

#1991 Feature #1991

#1704 Feature #1704

#2025 Feature #2025

#2109 Feature #2109

#899 Feature #899

#1815 Feature #1815

#1431 Feature #1431

#2039 Feature #2039

#767 Feature #767

#1244 Feature #1244

#2822 Feature #2822

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#208 Feature #208

#325 Feature #325

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#370 Feature #370

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#1205 Feature #1205

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#607 Feature #607

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#1858 Feature #1858

#2723 Feature #2723

#2608 Feature #2608

#1087 Feature #1087

#695 Feature #695

#2227 Feature #2227

#971 Feature #971

#1007 Feature #1007

#1509 Feature #1509

#2715 Feature #2715

#1185 Feature #1185

#1920 Feature #1920

#476 Feature #476

#316 Feature #316

#2503 Feature #2503

#2260 Historical Context & Development

#1317 Feature #1317

#2381 Feature #2381

#2320 Feature #2320

#932 Feature #932

#1063 Feature #1063

#2425 Feature #2425

#3032 Feature #3032

#2789 Feature #2789

#1481 Feature #1481

#297 Feature #297

#2623 Feature #2623

#179 Feature #179

#892 Feature #892

#430 Feature #430

#1295 Feature #1295

#286 Feature #286

#1973 Feature #1973

#138 Feature #138

#2755 Feature #2755

#2870 Feature #2870

#2045 Feature #2045

#2440 Feature #2440

#2437 Feature #2437

#2681 Feature #2681

#53 Feature #53

#403 Feature #403

#1229 Feature #1229

#2014 Feature #2014

#2858 Feature #2858

#1739 Feature #1739

#1691 Feature #1691

#1992 Feature #1992

#358 Feature #358

#556 Feature #556

#2339 Feature #2339

#842 Feature #842

#3001 Feature #3001

#2788 Feature #2788

#2732 Feature #2732

#250 Feature #250

#1388 Feature #1388

#515 Feature #515

#2785 Feature #2785

#1797 Feature #1797

#2146 Feature #2146

#525 Feature #525

#2461 Feature #2461

#1237 Feature #1237

#2561 Feature #2561

#2190 Feature #2190

#185 Feature #185

#1066 Feature #1066

#223 Feature #223

#1248 Feature #1248

#253 Feature #253

#588 Feature #588

#268 Feature #268

#2255 Feature #2255

#416 Feature #416

#905 Feature #905

#1758 Feature #1758

#886 Feature #886

#1819 Feature #1819

#313 Feature #313

#1681 Feature #1681

#177 Feature #177

#2306 Feature #2306

#2254 Feature #2254

#2292 Feature 2292

#222 Feature #222

#1837 Feature #1837

#1495 Feature #1495

#1660 Feature #1660

#2010 Feature #2010

#1513 Feature #1513

#1312 Feature #1312

#528 Feature #528

#2454 Feature #2454

#2646 Feature #2646

#2516 Feature #2516

#1113 Feature #1113

#2563 Feature #2563

#1456 Feature #1456

#1829 Feature #1829

#1148 Feature #1148

#578 Feature #578

#891 Feature #891

#2041 Feature #2041

#2972 Sensory-Motor Integration

#307 Feature #307

#2436 Feature #2436

#1223 Feature #1223

#2676 Feature #2676

#2481 Feature #2481

#2580 Feature #2580

#2209 Feature #2209

#2487 Feature #2487

#958 Feature #958

#2945 Feature 2945

#2089 Feature 2089

#524 Feature #524

#1072 Feature #1072

#150 Feature #150

#1777 Feature #1777

#1625 Feature #1625

#2535 Feature #2535

#2585 Feature #2585

#2669 Feature #2669

#2985 Feature #2985

#1686 Feature #1686

#2698 Feature #2698

#2999 Feature #2999

#221 Feature #221

#2903 Feature #2903

#1964 Feature #1964

#2163 Feature #2163

#1196 Feature #1196

#2886 Feature #2886

#2553 Feature #2553

#1323 Feature #1323

#1422 Feature #1422

#2643 Feature #2643

#633 Feature #633

#1749 Feature #1749

#1265 Feature #1265

#770 Feature #770

#231 Feature #231

#2265 Feature #2265

#111 Feature #111

#845 Feature #845

#3049 Feature #3049

#2079 Feature #2079

#1452 Feature #1452

#981 Feature #981

#1094 Feature #1094

#2404 Feature #2404

#3023 Feature #3023

#2097 Feature #2097

#600 Feature #600

#2229 Feature #2229

#2807 Feature #2807

#475 Feature #475

#1869 Feature #1869

#1197 Feature #1197

#2283 Feature #2283

#481 Feature #481

#2748 Feature #2748

#1286 Feature #1286

#2532 Feature #2532

#2028 Feature #2028

#2598 Feature #2598

#50 Feature #50

#2408 Feature #2408

#617 Feature #617

#2992 Feature #2992

#3006 Feature #3006

#2846 Feature #2846

#2527 Feature #2527

#1494 Feature #1494

#1671 Feature #1671

#2204 Feature #2204

#1056 Feature #1056

#1570 Feature #1570

#1232 Feature #1232

#249 Feature #249

#1845 Feature #1845

#1538 Feature #1538

#1738 Feature #1738

#1726 Feature #1726

#1000 Feature #1000

#190 Feature #190

#2946 Feature #2946

#2042 Feature #2042

#841 Feature #841

#956 Feature #956

#2394 Feature #2394

#1925 Feature #1925

#1447 Feature #1447

#1628 Feature #1628

#519 Feature #519

#874 Feature #874

#2519 Feature #2519

#1763 Feature #1763

#1360 Feature #1360

#2422 Feature #2422

#1055 Feature #1055

#133 Feature #133

#2498 Feature #2498

#1828 Feature #1828

#2483 Feature #2483

#518 Feature #518

#2135 Feature #2135

#1607 Feature #1607

#2432 Feature #2432

#33 Feature #33

#1200 Feature #1200

#1633 Feature #1633

#898 Feature #898

#739 Feature #739

#482 Feature #482

#1369 Feature #1369

#1383 Feature #1383

#2677 Feature #2677

#128 Feature #128

#572 Feature #572

#1760 Feature #1760

#1139 Feature #1139

#577 Feature #577

#1088 Feature #1088

#714 Feature #714

#1719 Feature #1719

#2733 Feature #2733

#2318 Feature #2318

#2995 Feature #2995

#1908 Feature #1908

#2533 Feature #2533

#374 Medical Imaging and Oncology

#1901 Feature #1901

#749 Feature #749

#2348 Feature #2348

#961 Feature #961

#2909 Feature #2909

#1458 Feature #1458

#243 Feature #243

#2716 Feature #2716

#427 Feature #427

#380 Feature #380

#2030 Feature #2030

#1793 Feature #1793

#2156 Feature #2156

#2399 Feature #2399

#1318 Feature #1318

#1993 Feature #1993

#1903 Feature #1903

#1677 Feature #1677

#980 Feature #980

#2223 Feature #2223

#1523 Feature #1523

#1184 Feature #1184

#1927 Feature #1927

#2121 Feature #2121

#836 Feature #836

#79 Feature #79

#220 Feature #220

#1516 Feature #1516

#2243 Feature #2243

#1877 Feature #1877

#1399 Feature #1399

#1276 Feature #1276

#1101 Feature #1101

#3022 Feature #3022

#1646 Feature #1646

#1217 Feature #1217

#13 Feature #13

#877 Feature #877

#516 Feature #516

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#108 Feature #108

#2963 Feature #2963

#2704 Feature #2704

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#1308 Feature #1308

#541 Feature #541

#2184 Feature #2184

#251 Feature #251

#2372 Feature #2372

#839 Feature #839

#1960 Feature #1960

#2022 Feature #2022

#2351 Feature #2351

#1182 Feature #1182

#2526 Feature #2526

#2772 Feature #2772

#647 Feature #647

#530 Feature #530

#1924 Feature #1924

#536 Feature #536

#2003 Feature #2003

#1956 Feature #1956

#2687 Feature #2687

#3070 Spiritual and Holistic Care in Healthcare

#2737 Feature #2737

#1970 Feature #1970

#3026 Feature #3026

#1434 Feature #1434

#83 Feature #83

#2518 Feature #2518

#1160 Feature #1160

#1612 Feature #1612

#302 Feature #302

#2573 Feature #2573

#2074 Feature #2074

#1914 Feature #1914

#3037 Feature #3037

#2305 Feature #2305

#2336 Feature #2336

#1449 Feature #1449

#2567 Feature #2567

#786 Feature 786

#1761 Feature #1761

#45 Feature #45

#112 Feature #112

#2447 Feature #2447

#1893 Feature #1893

#2976 Feature #2976

#1890 Feature #1890

#2510 Feature #2510

#1238 Feature #1238

#2720 Feature #2720

#2271 Feature #2271

#776 Feature #776

#2802 Feature #2802

#2546 Feature #2546

#2940 Feature #2940

#392 Feature #392

#409 Feature #409

#1586 Feature #1586

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#2538 Feature #2538

#1658 Feature #1658

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#1755 Feature #1755

#1526 Feature #1526

#1012 Feature #1012

#1700 Feature #1700

#2323 Feature #2323

#1852 Feature #1852

#2885 Feature #2885

#2531 Feature #2531

#390 Feature #390

#3053 Feature #3053

#2907 Feature #2907

#2628 Feature #2628

#2087 Feature #2087

#255 Feature #255

#158 Feature #158

#2617 Feature #2617

#857 Feature #857

#2403 Feature #2403

#1125 Feature #1125

#237 Feature #237

#2473 Feature #2473

#576 Feature #576

#3042 Feature 3042

#1592 Feature #1592

#1050 Feature #1050

#2421 Feature #2421

#319 Feature #319

#97 Feature #97

#1263 Feature #1263

#1861 Feature #1861

#777 Feature #777

#452 Feature #452

#1821 Feature #1821

#689 Feature #689

#100 Feature #100

#1247 Feature #1247

#344 Feature #344

#1714 Feature #1714

#1549 Feature #1549

#2199 Feature #2199

#1870 Feature #1870

#1391 Feature #1391

#2649 Feature #2649

#2068 Feature #2068

#1802 Feature #1802

#1767 Feature #1767

#1013 Feature #1013

#2088 Feature #2088

#976 Feature #976

#2709 Feature #2709

#1839 Feature #1839

#435 Feature #435

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#2624 Feature #2624

#189 Feature #189

#783 Feature #783

#1251 Feature #1251

#1375 Feature #1375

#2373 Feature #2373

#2103 Feature #2103

#1231 Feature #1231

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#809 Feature #809

#17 Feature #17

#873 Feature #873

#1642 Feature #1642

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#1504 Feature #1504

#2761 Feature #2761

#771 Feature #771

#1352 Feature #1352

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#930 Feature #930

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#860 Feature #860

#1926 Feature #1926

#562 Feature #562

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#1696 Feature #1696

#1239 Feature #1239

#880 Feature #880

#52 Feature #52

#199 Feature #199

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#824 Feature #824

#492 Feature #492

#2245 Feature #2245

#623 Feature #623

#646 Feature #646

#1398 Feature #1398

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#723 Feature #723

#1227 Feature #1227

#2353 Feature #2353

#1046 Feature #1046

#420 Feature #420

#2746 Feature #2746

#1673 Feature #1673

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#1514 Feature #1514

#1187 Feature #1187

#1981 Feature #1981

#884 Feature #884

#897 Feature #897

#2464 Feature #2464

#130 Feature #130

#687 Feature #687

#1506 Justification/Rationale for Actions

#110 Feature #110

#2232 Medical Case Reports & Cancer Research

#2205 Feature #2205

#1999 Feature #1999

#271 Feature #271

#2798 Feature #2798

#1652 Feature #1652

#2048 Feature #2048

#710 Feature #710

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#2237 Feature #2237

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#2082 Feature #2082

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#1545 Feature #1545

#1337 Feature #1337

#2524 Feature #2524

#1181 Feature #1181

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#2682 Feature 2682

#1972 Feature 1972

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#850 Feature #850

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#1222 Feature #1222

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#2099 Feature #2099

#1909 Feature #1909

#362 Feature #362

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#2026 Feature #2026

#2402 Feature #2402

#2471 Feature #2471

#1709 Feature #1709

#309 Feature #309

#1866 Feature #1866

#1274 Feature #1274

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#2939 Feature #2939

#1665 Feature #1665

#1996 Feature #1996

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#1919 Feature #1919

#2188 Feature #2188

#1952 Feature #1952

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#102 Feature #102

#1576 Feature #1576

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#413 Feature #413

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#543 Feature #543

#1428 Feature #1428

#44 Feature #44

#2341 Feature #2341

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#1620 Feature #1620

#1816 Feature #1816

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#2749 Feature #2749

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#2969 Feature #2969

#1043 Feature #1043

#356 Feature #356

#1725 Feature #1725

#1497 Feature #1497

#2185 Feature #2185

#677 Feature #677

#1971 Feature #1971

#2191 Feature #2191

#1623 Feature #1623

#2007 Developmental Disparities & Intervention

#1058 Feature #1058

#2377 Feature #2377

#2343 Feature #2343

#2950 Feature #2950

#2900 Feature #2900

#1611 Feature #1611

#1731 Feature #1731

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#569 Feature #569

#659 Feature #659

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#1657 Feature #1657

#2780 Feature #2780

#2672 Feature #2672

#1550 Feature #1550

#1322 Feature #1322

#2637 Feature #2637

#257 Feature #257

#1039 Feature #1039

#2997 Feature #2997

#1732 Feature #1732

#2991 Feature #2991

#80 Feature #80

#1379 Feature #1379

#2955 Feature #2955

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#829 Feature #829

#2668 Feature #2668

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#632 Feature #632

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#16 Feature #16

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#357 Feature #357

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#911 Feature #911

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#15 Feature #15

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#778 Feature #778

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#881 Feature #881

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#2699 Feature #2699

#215 Feature #215

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#1152 Feature #1152

#101 Feature #101

#1406 Feature #1406

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#665 Feature #665

#1270 Feature #1270

#643 Feature #643

#3058 Feature #3058

#923 Feature #923

#814 Feature #814

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#2922 Feature #2922

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#2827 Feature #2827

#656 Feature #656

#1728 Feature #1728

#580 Feature #580

#1020 Feature #1020

#2157 Feature #2157

#107 Feature #107

#502 Feature #502

#1699 Feature #1699

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#2658 Feature #2658

#819 Feature #819

#1588 Feature #1588

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#2197 Feature #2197

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#14 Feature #14

#645 Feature #645

#2816 Feature #2816

#933 Feature #933

#1694 Feature #1694

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#1195 Feature #1195

#397 Feature #397

#909 Feature #909

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#1822 Feature 1822

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#1073 Feature #1073

#1178 Feature #1178

#1773 Feature #1773

#2453 Feature #2453

#972 Feature #972

#801 Feature #801

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#538 Feature #538

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#394 Feature #394

#1439 Feature #1439

#66 Feature #66

#1107 Feature #1107

#2050 Feature #2050

#274 Feature 274

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#2158 Feature #2158

#1530 Feature #1530

#1634 Feature #1634

#2263 Feature #2263

#1016 Feature #1016

#2361 Feature #2361

#2710 Feature #2710

#2021 Feature #2021

#790 Feature #790

#2910 Feature #2910

#2691 Feature #2691

#2337 Feature #2337

#3015 Feature #3015

#2085 Feature #2085

#1436 Feature #1436

#2002 Feature #2002

#1864 Feature #1864

#1934 Feature #1934

#2574 Feature #2574

#2480 Feature #2480

#2904 Feature #2904

#2686 Feature #2686

#986 Feature #986

#2304 Feature #2304

#927 Feature #927

#508 Feature #508

#1796 Feature #1796

#127 Feature #127

#554 Feature #554

#2374 Feature #2374

#23 Neuronal Circuitry and Cellular Processes

#2439 Feature #2439

#1631 Feature #1631

#1433 Feature #1433

#1443 Feature #1443

#1498 Feature #1498

#22 Feature #22

#1636 Feature #1636

#2867 Feature #2867

#2520 Feature #2520

#2368 Feature #2368

#42 Feature #42

#1293 Feature #1293

#1847 Feature #1847

#1794 Feature #1794

#497 Feature #497

#1922 Feature #1922

#285 Feature #285

#1907 Feature #1907

#2528 Feature #2528

#1084 Feature #1084

#1209 Feature #1209

#2591 Feature #2591

#991 Feature #991

#1233 Feature #1233

#811 Feature #811

#2264 Feature #2264

#2747 Feature #2747

#2958 Feature #2958

#2633 Feature #2633

#559 Feature #559

#121 Feature #121

#1038 Feature #1038

#1324 Feature #1324

#1643 Feature #1643

#2864 Feature #2864

#662 Feature #662

#2049 Feature #2049

#2342 Feature #2342

#338 Feature #338

#1518 Feature #1518

#894 Feature #894

#1540 Feature #1540

#2674 Feature #2674

#1997 Feature #1997

#2076 Feature #2076

#1765 Feature #1765

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Document Content

Efficacy of various doses and schedules of second-generation tyrosine kinase inhibitors.
Imatinib is one of the most potent cancer therapeutic agents identified to date. Before the introduction of this tyrosine kinase inhibitor (TKI), 5-year survival in chronic myeloid leukemia (CML) was approximately 40%-60%, but since the introduction of imatinib, overall survival has increased to approximately 90% for patients with chronic-phase disease. However, nearly one fifth of patients are intolerant or resistant to imatinib, resulting in patients with persistent or progressive disease. Recent research has identified a number of additional compounds that more efficiently inhibit the Abl tyrosine kinase and additional kinases that potentially play a role in imatinib resistance. The advent of dasatinib and nilotinib has provided additional options for patients with progressive disease. A number of phase II clinical trials have recently demonstrated that these second-generation TKIs are well tolerated and effective in patients with Philadelphia chromosome-positive (Ph+) leukemias. Recent clinical trial developments raise questions regarding the proper dosage and schedule of these newer agents as well as the timing of their use in the treatment of patients with CML. Additionally, the development of nonoverlapping resistance patterns with sequential drug exposure argues for the possibility of a drug selection scheme that might limit the development of resistant disease. As the era of personalized medicine has begun to take shape in the 21st century, the addition of newer TKIs might facilitate this trend in the treatment of Ph+ leukemias.

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