Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1493

MIN ACTIVATION

0.0

Details List

#1479 Feature 1479

#378 Feature 378

#1190 Feature 1190

#2821 Feature 2821

#1339 Feature 1339

#319 Feature 319

#2373 Feature 2373

#806 Feature 806

#534 Feature 534

#2336 Feature 2336

#2713 Feature 2713

#1320 Feature 1320

#2210 Feature 2210

#287 Feature 287

#2164 Feature 2164

#1741 Feature #1741

#1009 Feature 1009

#1794 Feature 1794

#1139 Feature 1139

#677 Feature 677

#945 Feature 945

#1638 Feature #1638

#2392 Feature 2392

#1704 Feature 1704

#1036 Feature #1036

#2370 Feature 2370

#2827 Feature 2827

#1334 Feature #1334

#1562 Feature #1562

#2302 Feature 2302

#1289 Feature 1289

#2766 Feature 2766

#239 Feature 239

#2516 Feature 2516

#2105 Feature 2105

#2247 Feature 2247

#1914 Feature 1914

#2175 Feature 2175

#993 Feature 993

#1015 Feature 1015

#1303 Feature 1303

#1352 Feature 1352

#2081 Feature 2081

#909 Feature 909

#1482 Feature 1482

#1466 Feature 1466

#823 Feature 823

#2575 Feature 2575

#963 Feature #963

#351 Nanomaterial Synthesis and Properties

#947 Feature 947

#2094 Feature 2094

#2896 Feature 2896

#1701 Feature 1701

#681 Feature 681

#2365 Feature 2365

#3042 Feature 3042

#1573 Feature 1573

#1925 Feature 1925

#2012 Feature 2012

#1285 Feature 1285

#2118 Feature 2118

#1180 Feature 1180

#2950 Feature 2950

#1419 Feature 1419

#844 Feature #844

#1630 Feature 1630

#162 Feature 162

#2756 Feature 2756

#352 Feature 352

#685 Feature 685

#169 Feature 169

#545 Feature 545

#1868 Feature 1868

#1300 Feature #1300

#1781 Feature 1781

#2078 Feature 2078

#1433 Feature 1433

#1589 Feature 1589

#1232 Feature 1232

#2661 Feature 2661

#458 Feature 458

#2318 Feature 2318

#1971 Feature 1971

#2565 Feature 2565

#1159 Feature 1159

#2566 Feature 2566

#1517 Feature 1517

#619 Feature 619

#381 Feature 381

#1098 Feature 1098

#709 Feature 709

#894 Feature 894

#303 Feature 303

#380 Feature 380

#1165 Feature 1165

#3022 Feature 3022

#722 Feature 722

#431 Feature #431

#2862 Feature 2862

#800 Feature 800

#2216 Feature 2216

#772 Feature 772

#1024 Feature 1024

#189 Feature 189

#1313 Feature 1313

#870 Feature 870

#1034 Feature 1034

#1372 Feature 1372

#816 Feature 816

#505 Feature #505

#2610 Feature 2610

#886 Feature 886

#1176 Feature 1176

#1643 Feature 1643

#520 Feature 520

#2001 Feature 2001

#302 Feature 302

#1855 Feature #1855

#1209 Feature 1209

#1397 Feature 1397

#1179 Feature 1179

#2428 Feature #2428

#1250 Feature 1250

#1091 Feature 1091

#1921 Feature 1921

#1242 Feature #1242

#1611 Feature 1611

#1902 Feature #1902

#1095 Feature 1095

#1975 Feature 1975

#2240 Feature 2240

#255 Feature 255

#683 Feature 683

#1452 Feature #1452

#1414 Feature #1414

#1893 Feature 1893

#1358 Feature 1358

#2683 Feature #2683

#2819 Feature 2819

#1302 Sensing and Detection Technologies

#964 Feature #964

#2745 Feature 2745

#2593 Feature 2593

#796 Feature 796

#2788 Feature #2788

#2292 Feature 2292

#2145 Feature #2145

#1230 Feature #1230

#662 Feature #662

#653 Feature 653

#1731 Feature 1731

#2648 Feature #2648

#2801 Feature 2801

#1818 Feature 1818

#1804 Feature 1804

#1590 Feature 1590

#2099 Feature 2099

#1120 Feature 1120

#2358 Feature 2358

#1750 Feature 1750

#551 Feature 551

#3062 Feature #3062

#2335 Feature 2335

#2325 Feature 2325

#1958 Feature #1958

#3061 Feature #3061

#369 Feature 369

#2992 Feature 2992

#277 Feature #277

#1782 Feature 1782

#2735 Feature 2735

#1976 Feature 1976

#2889 Feature #2889

#509 Feature 509

#416 Feature 416

#2522 Feature #2522

#2160 Feature 2160

#1749 Feature 1749

#2380 Feature 2380

#2934 Feature 2934

#1793 Feature 1793

#1465 Feature 1465

#2626 Feature 2626

#1328 Feature #1328

#591 Feature 591

#1776 Feature 1776

#2450 Feature #2450

#2076 Feature 2076

#3052 Feature 3052

#1872 Feature 1872

#937 Feature 937

#1907 Feature 1907

#1319 Feature 1319

#1568 Feature 1568

#1796 Feature #1796

#2500 Feature 2500

#974 Feature 974

#628 Feature 628

#1572 Feature 1572

#221 Feature #221

#782 Feature #782

#190 Feature 190

#1469 Feature 1469

#1650 Feature #1650

#1476 Feature 1476

#2867 Feature 2867

#728 Feature 728

#1974 Feature 1974

#1089 Feature 1089

#2396 Feature 2396

#584 Feature 584

#1113 Feature 1113

#1067 Feature 1067

#2933 Feature 2933

#1754 Feature #1754

#1614 Feature 1614

#1846 Feature 1846

#2747 Feature 2747

#2597 Feature 2597

#731 Feature 731

#872 Feature 872

#835 Feature #835

#1092 Feature 1092

#473 Feature #473

#1728 Feature 1728

#828 Feature 828

#1138 Feature 1138

#1839 Feature 1839

#2414 Feature 2414

#518 Feature 518

#2707 Feature 2707

#946 Feature 946

#2465 Feature 2465

#1375 Feature 1375

#1801 Feature 1801

#2034 Feature #2034

#1394 Feature 1394

#2524 Feature 2524

#1188 Feature 1188

#395 Feature 395

#2170 Feature 2170

#436 Feature 436

#1280 Feature 1280

#785 Feature 785

#1564 Feature 1564

#2416 Feature 2416

#1693 Feature 1693

#116 Feature 116

#1265 Feature #1265

#563 Feature 563

#2927 Feature #2927

#1136 Feature 1136

#2836 Feature 2836

#100 Feature 100

#1934 Feature 1934

#1068 Feature #1068

#2893 Feature 2893

#2193 Feature 2193

#267 Feature 267

#2319 Feature 2319

#2996 Feature 2996

#1344 Feature 1344

#2412 Feature 2412

#1789 Feature 1789

#149 Feature 149

#2491 Feature 2491

#1448 Feature 1448

#2098 Feature #2098

#330 Feature #330

#2937 Feature 2937

#750 Feature #750

#331 Feature 331

#1891 Feature 1891

#912 Feature #912

#678 Feature 678

#2475 Feature 2475

#177 Feature #177

#2102 Feature 2102

#2326 Feature #2326

#798 Feature #798

#606 Feature #606

#1215 Feature 1215

#2851 Feature 2851

#1703 Feature 1703

#2301 Feature 2301

#2926 Feature 2926

#1677 Feature 1677

#758 Feature 758

#1580 Feature #1580

#2000 Feature 2000

#2083 Feature 2083

#1171 Feature 1171

#1102 Feature #1102

#1998 Feature 1998

#740 Feature #740

#2294 Feature 2294

#1415 Feature 1415

#2705 Feature 2705

#2063 Feature #2063

#2046 Feature 2046

#1695 Feature 1695

#2554 Feature 2554

#561 Feature 561

#1833 Feature 1833

#558 Feature 558

#2157 Feature 2157

#936 Feature 936

#2028 Feature #2028

#801 Feature 801

#1117 Feature 1117

#1596 Feature #1596

#1683 Feature 1683

#2222 Feature 2222

#2427 Feature 2427

#1727 Feature 1727

#404 Interactions and Mechanisms

#2990 Feature 2990

#1768 Feature #1768

#2823 Feature #2823

#1441 Feature 1441

#2953 Feature 2953

#1045 Feature 1045

#407 Feature 407

#348 Feature 348

#1056 Feature 1056

#1576 Feature 1576

#613 Feature 613

#1721 Feature #1721

#3027 Feature 3027

#652 Feature 652

#624 Feature 624

#881 Feature #881

#1440 Feature #1440

#1197 Feature #1197

#1538 Feature 1538

#1157 Feature #1157

#1256 Feature 1256

#1501 Feature 1501

#2286 Feature 2286

#733 Feature 733

#952 Feature 952

#2257 Feature 2257

#2444 Feature 2444

#2758 Feature 2758

#1651 Feature 1651

#1153 Feature 1153

#2433 Feature 2433

#550 Feature 550

#449 Feature 449

#1047 Feature 1047

#409 Feature 409

#2864 Feature #2864

#497 Feature 497

#846 Feature 846

#2386 Feature 2386

#1951 Feature 1951

#1565 Feature #1565

#2349 Feature 2349

#967 Feature #967

#2258 Feature 2258

#305 Feature #305

#1442 Feature #1442

#2815 Feature #2815

#1384 Feature 1384

#913 Feature #913

#1680 Feature 1680

#2832 Feature 2832

#1988 Feature 1988

#293 Feature 293

#121 Feature 121

#2264 Feature 2264

#104 Feature 104

#482 Feature 482

#2792 Feature #2792

#2762 Feature 2762

#1881 Feature #1881

#1670 Feature 1670

#1257 Feature 1257

#2203 Feature 2203

#944 Feature 944

#1325 Feature 1325

#1852 Feature 1852

#693 Feature 693

#1812 Feature 1812

#1513 Feature 1513

#2956 Feature 2956

#3071 Feature 3071

#732 Feature 732

#2696 Feature 2696

#901 Feature #901

#151 Feature 151

#1461 Feature #1461

#2816 Feature 2816

#2539 Feature 2539

#1729 Feature #1729

#977 Feature #977

#1923 Feature 1923

#1029 Feature #1029

#1321 Feature #1321

#1526 Feature 1526

#2146 Feature #2146

#2991 Feature 2991

#1853 Feature 1853

#2299 Feature #2299

#1747 Feature #1747

#2323 Feature 2323

#1109 Feature 1109

#2854 Feature 2854

#1542 Feature #1542

#1843 Feature 1843

#2960 Feature #2960

#554 Feature 554

#955 Feature 955

#444 Feature 444

#2483 Feature 2483

#2729 Feature 2729

#1858 Feature 1858

#1263 Feature 1263

#1000 Feature #1000

#2277 Feature 2277

#565 Feature 565

#1454 Feature 1454

#773 Feature #773

#2397 Feature 2397

#2187 Feature 2187

#1787 Feature #1787

#1198 Feature #1198

#2979 Feature 2979

#2077 Feature 2077

#1957 Feature 1957

#932 Feature 932

#1032 Feature #1032

#2212 Feature 2212

#2772 Feature 2772

#2198 Feature 2198

#256 Feature 256

#1632 Feature 1632

#1154 Feature #1154

#1991 Feature 1991

#2025 Feature 2025

#815 Feature #815

#654 Feature #654

#923 Feature 923

#2555 Feature 2555

#1496 Feature 1496

#200 Feature 200

#2338 Feature 2338

#884 Feature #884

#1507 Feature #1507

#2014 Feature 2014

#235 Feature #235

#1200 Feature #1200

#2282 Feature #2282

#1390 Feature 1390

#2511 Feature 2511

#2988 Feature 2988

#762 Feature 762

#1208 Feature 1208

#224 Feature 224

#1675 Feature 1675

#1555 Feature 1555

#1828 Feature #1828

#2970 Feature 2970

#2561 Feature #2561

#575 Feature 575

#2974 Feature 2974

#1676 Feature 1676

#2461 Feature 2461

#2009 Feature 2009

#3070 Spiritual and Holistic Care in Healthcare

#2020 Feature 2020

#1332 Feature 1332

#1503 Feature 1503

#1251 Feature #1251

#2984 Feature 2984

#1512 Feature #1512

#1284 Feature 1284

#105 Feature 105

#776 Feature 776

#468 Feature #468

#2140 Feature 2140

#1084 Feature 1084

#2387 Feature 2387

#1447 Feature 1447

#1673 Feature 1673

#2348 Feature 2348

#3055 Feature 3055

#1583 Feature 1583

#2968 Feature 2968

#2580 Feature #2580

#1424 Feature 1424

#1235 Feature #1235

#2215 Feature 2215

#1901 Feature 1901

#1575 Feature #1575

#2961 Feature 2961

#1463 Feature #1463

#2413 Feature 2413

#675 Feature #675

#2474 Feature #2474

#648 Feature 648

#1800 Feature 1800

#887 Feature #887

#1896 Feature 1896

#1085 Feature 1085

#2814 Feature #2814

#159 Feature 159

#2152 Feature #2152

#911 Feature 911

#2389 Feature 2389

#261 Feature 261

#2129 Feature 2129

#1848 Feature 1848

#848 Feature #848

#543 Feature 543

#2208 Feature 2208

#1353 Feature 1353

#1246 Feature 1246

#1504 Feature #1504

#1455 Feature 1455

#288 Feature 288

#994 Feature 994

#697 Feature #697

#1065 Feature 1065

#3066 Feature 3066

#266 Feature #266

#871 Feature #871

#1370 Feature 1370

#1797 Feature 1797

#120 Feature 120

#1558 Feature #1558

#2206 Feature 2206

#1151 Feature #1151

#609 Feature 609

#2602 Feature 2602

#707 Feature 707

#2668 Feature #2668

#862 Feature 862

#1788 Feature 1788

#2587 Feature 2587

#2697 Feature 2697

#2493 Feature 2493

#2209 Feature 2209

#2545 Feature 2545

#1124 Feature 1124

#2172 Feature 2172

#113 Feature #113

#2079 Feature 2079

#2895 Feature 2895

#2740 Feature 2740

#1598 Feature 1598

#504 Feature 504

#2967 Feature 2967

#1483 Feature #1483

#1259 Feature 1259

#1543 Feature #1543

#1398 Feature 1398

#984 Feature 984

#2159 Feature 2159

#2907 Feature #2907

#1746 Feature #1746

#804 Feature 804

#941 Feature #941

#2704 Feature 2704

#2809 Feature 2809

#2666 Feature #2666

#1473 Feature #1473

#1892 Feature #1892

#2794 Feature 2794

#795 Feature 795

#1412 Feature 1412

#1681 Feature #1681

#448 Feature 448

#1779 Feature 1779

#1716 Feature 1716

#852 Feature #852

#1622 Feature 1622

#1763 Feature 1763

#1527 Feature 1527

#1965 Feature #1965

#1137 Feature 1137

#2998 Feature 2998

#2905 Feature #2905

#658 Feature 658

#2588 Feature 2588

#2072 Feature 2072

#2184 Feature 2184

#2458 Feature 2458

#2732 Feature 2732

#2274 Feature 2274

#1599 Feature #1599

#350 Feature #350

#3038 Feature 3038

#1337 Feature 1337

#1420 Feature 1420

#1205 Feature 1205

#809 Feature 809

#1569 Feature #1569

#500 Feature 500

#2424 Feature 2424

#460 Feature 460

#2158 Feature #2158

#2739 Feature 2739

#285 Feature 285

#2067 Feature #2067

#2985 Feature #2985

#1464 Feature 1464

#702 Feature 702

#1196 Feature 1196

#2217 Feature 2217

#2767 Feature 2767

#1546 Feature 1546

#1105 Feature 1105

#618 Feature 618

#1011 Feature 1011

#780 Feature 780

#1571 Feature 1571

#2900 Feature 2900

#2384 Feature 2384

#1306 Feature #1306

#1184 Feature 1184

#1930 Feature #1930

#1403 Feature 1403

#2513 Feature 2513

#1430 Feature 1430

#3069 Feature 3069

#2658 Feature #2658

#1696 Feature #1696

#1359 Feature 1359

#2005 Feature 2005

#2868 Feature #2868

#777 Feature #777

#1494 Feature 1494

#2718 Feature 2718

#2634 Feature 2634

#233 Feature 233

#2628 Feature #2628

#424 Feature 424

#310 Feature 310

#2030 Feature 2030

#1278 Feature 1278

#202 Feature #202

#2520 Feature 2520

#1867 Feature 1867

#1444 Feature #1444

#1699 Feature 1699

#799 Feature 799

#2486 Feature #2486

#2290 Feature 2290

#1928 Feature 1928

#2447 Feature 2447

#692 Feature 692

#2618 Feature #2618

#2574 Feature #2574

#2488 Feature 2488

#2220 Feature 2220

#1906 Feature 1906

#1522 Feature 1522

#2517 Feature #2517

#2807 Feature #2807

#1854 Feature 1854

#734 Feature 734

#492 Feature 492

#1364 Feature #1364

#2191 Feature 2191

#701 Feature #701

#1402 Feature 1402

#422 Feature #422

#2367 Feature #2367

#873 Feature 873

#641 Feature 641

#900 Feature 900

#598 Feature 598

#360 Feature 360

#2484 Feature #2484

#2646 Feature 2646

#1058 Feature 1058

#2637 Feature 2637

#1824 Feature 1824

#1990 Feature 1990

#2675 Feature 2675

#1578 Feature #1578

#358 Feature 358

#2848 Feature 2848

#1219 Feature 1219

#3008 Feature 3008

#1688 Feature 1688

#1178 Feature 1178

#3034 Feature 3034

#2376 Feature 2376

#1751 Feature 1751

#2645 Feature 2645

#1918 Feature 1918

#1396 Feature 1396

#588 Feature 588

#986 Feature #986

#1335 Feature 1335

#753 Feature 753

#2899 Feature 2899

#1592 Feature 1592

#1299 Feature #1299

#1817 Feature 1817

#1980 Feature 1980

#1775 Feature #1775

#2686 Feature 2686

#185 Feature 185

#2682 Feature 2682

#928 Feature 928

#2128 Feature #2128

#580 Feature 580

#2834 Feature 2834

#1607 Feature 1607

#1012 Feature 1012

#2607 Feature 2607

#2410 Feature 2410

#2342 Feature 2342

#1175 Feature 1175

#2443 Feature 2443

#2777 Feature 2777

#2969 Feature 2969

#966 Feature 966

#2622 Feature 2622

#1316 Feature 1316

#991 Feature #991

#2485 Feature 2485

#2727 Feature 2727

#1233 Feature 1233

#2100 Feature 2100

#1279 Feature 1279

#487 Feature 487

#229 Feature 229

#802 Feature 802

#366 Feature #366

#1474 Feature 1474

#1017 Feature 1017

#570 Feature 570

#3039 Feature #3039

#2856 Feature 2856

#336 Feature #336

#788 Feature 788

#1766 Feature 1766

#2494 Feature 2494

#1195 Feature 1195

#173 Feature 173

#2995 Feature #2995

#419 Feature 419

#1021 Feature #1021

#2298 Feature #2298

#3015 Feature #3015

#541 Feature 541

#1123 Feature 1123

#2400 Feature 2400

#1798 Feature 1798

#688 Feature #688

#956 Feature 956

#357 Feature 357

#2512 Feature 2512

#769 Feature #769

#2842 Feature 2842

#2585 Feature 2585

#495 Feature 495

#3024 Feature #3024

#1075 Feature 1075

#1879 Feature 1879

#1553 Feature #1553

#1602 Feature 1602

#1446 Feature 1446

#2324 Feature 2324

#2781 Feature 2781

#981 Feature 981

#2437 Feature 2437

#1936 Feature 1936

#536 Feature #536

#1355 Feature 1355

#1268 Feature 1268

#3019 Feature 3019

#1240 Feature 1240

#1450 Feature 1450

#1389 Feature 1389

#2706 Feature 2706

#751 Feature 751

#875 Feature 875

#1835 Feature #1835

#1903 Feature #1903

#1107 Feature 1107

#1870 Feature #1870

#564 Feature #564

#172 Feature #172

#465 Feature #465

#975 Feature 975

#216 Feature #216

#1413 Feature 1413

#601 Feature 601

#980 Feature 980

#2543 Feature 2543

#524 Feature #524

#122 Feature 122

#2831 Feature 2831

#2577 Feature 2577

#1049 Feature 1049

#455 Feature #455

#306 Feature 306

#242 Feature 242

#494 Feature 494

#2754 Feature 2754

#2352 Feature 2352

#1740 Feature #1740

#2642 Feature 2642

#1192 Feature 1192

#2774 Feature #2774

#1642 Feature 1642

#720 Feature 720

#2533 Feature 2533

#2024 Feature 2024

#3012 Feature #3012

#2205 Feature 2205

#2156 Feature 2156

#3023 Feature 3023

#998 Feature #998

#1878 Feature 1878

#1110 Feature #1110

#2761 Feature #2761

#1528 Feature 1528

#1722 Feature #1722

#1245 Feature 1245

#2759 Feature 2759

#631 Feature #631

#292 Feature #292

#1694 Feature 1694

#2235 Feature 2235

#2357 Feature 2357

#225 Feature 225

#2869 Feature 2869

#2341 Feature 2341

#2605 Feature 2605

#2445 Feature 2445

#2337 Feature #2337

#1167 Feature 1167

#691 Feature #691

#690 Feature 690

#599 Feature 599

#1152 Feature #1152

#1770 Feature #1770

#2825 Feature #2825

#1547 Feature 1547

#1072 Feature #1072

#2943 Feature 2943

#2354 Feature #2354

#2846 Feature 2846

#2568 Feature 2568

#130 Feature 130

#1366 Feature 1366

#1023 Feature 1023

#1329 Feature 1329

#1283 Feature 1283

#178 Feature 178

#2547 Feature 2547

#1385 Feature 1385

#657 Feature 657

#2124 Feature #2124

#1898 Feature 1898

#499 Feature 499

#1457 Feature 1457

#1530 Feature #1530

#951 Feature #951

#646 Feature 646

#297 Feature 297

#748 Feature 748

#386 Feature 386

#1844 Feature 1844

#1069 Feature 1069

#996 Feature #996

#829 Feature #829

#706 Feature 706

#2151 Feature #2151

#2921 Feature #2921

#2233 Feature #2233

#1031 Feature 1031

#1944 Feature 1944

#294 Feature #294

#1910 Feature 1910

#1979 Feature 1979

#965 Feature 965

#464 Feature 464

#1706 Feature 1706

#1561 Feature #1561

#764 Feature 764

#415 Feature 415

#2037 Feature 2037

#1485 Feature #1485

#2330 Feature 2330

#1534 Feature #1534

#1467 Feature #1467

#1388 Feature 1388

#2654 Feature #2654

#150 Feature 150

#327 Feature 327

#1114 Feature #1114

#258 Feature 258

#283 Feature 283

#1962 Feature 1962

#1134 Feature 1134

#1019 Feature 1019

#1057 Feature 1057

#1392 Feature #1392

#1761 Feature 1761

#659 Feature 659

#643 Feature 643

#2948 Feature 2948

#1239 Feature 1239

#1298 Feature #1298

#1617 Feature 1617

#992 Feature 992

#2865 Feature 2865

#583 Feature 583

#328 Feature #328

#2036 Feature 2036

#278 Feature 278

#779 Feature 779

#375 Feature 375

#1587 Feature #1587

#2104 Feature #2104

#2994 Feature #2994

#1431 Feature #1431

#2300 Feature 2300

#1697 Feature #1697

#1399 Feature 1399

#1619 Feature 1619

#2638 Feature #2638

#1885 Feature 1885

#672 Feature 672

#2227 Feature #2227

#286 Feature 286

#3063 Feature 3063

#1100 Feature 1100

#2841 Feature #2841

#2438 Feature 2438

#2912 Feature 2912

#538 Feature 538

#1960 Feature #1960

#2426 Feature 2426

#2884 Feature 2884

#119 Feature 119

#1418 Feature 1418

#2383 Feature 2383

#1488 Feature #1488

#837 Feature #837

#539 Feature 539

#1537 Feature #1537

#2287 Feature 2287

#1432 Feature #1432

#1505 Feature 1505

#1211 Feature 1211

#1128 Feature 1128

#2003 Feature 2003

#1742 Feature #1742

#2097 Feature 2097

#831 Feature 831

#961 Feature 961

#1097 Feature 1097

#265 Feature 265

#1736 Feature 1736

#2200 Feature 2200

#2843 Feature #2843

#2476 Feature 2476

#175 Feature 175

#1894 Feature 1894

#2188 Feature 2188

#548 Feature 548

#1644 Feature 1644

#326 Feature 326

#2673 Feature 2673

#316 Feature #316

#1735 Feature 1735

#476 Feature 476

#1863 Feature 1863

#2808 Feature 2808

#1062 Feature #1062

#244 Feature 244

#1434 Feature 1434

#260 Feature #260

#1816 Feature 1816

#2858 Feature 2858

#2270 Feature 2270

#2725 Feature 2725

#2381 Feature 2381

#223 Feature 223

#196 Feature 196

#1248 Feature #1248

#2550 Feature #2550

#2093 Feature 2093

#1193 Feature 1193

#1087 Feature 1087

#978 Feature #978

#2710 Feature 2710

#2421 Feature #2421

#2576 Feature 2576

#833 Feature #833

#2455 Feature #2455

#2693 Feature #2693

#2613 Feature #2613

#608 Feature #608

#3040 Feature 3040

#2728 Feature 2728

#1820 Feature #1820

#530 Feature #530

#3041 Feature #3041

#2544 Feature 2544

#1769 Feature 1769

#1025 Feature 1025

#2351 Feature 2351

#1127 Feature 1127

#1795 Feature 1795

#2571 Feature 2571

#2918 Feature #2918

#2612 Feature #2612

#1074 Feature 1074

#2448 Feature #2448

#2147 Feature #2147

#866 Feature #866

#2973 Feature #2973

#1567 Feature #1567

#568 Feature #568

#2114 Feature 2114

#1594 Feature 1594

#1428 Feature 1428

#2321 Feature 2321

#425 Feature 425

#506 Feature 506

#370 Feature 370

#2457 Feature 2457

#123 Feature 123

#1308 Feature 1308

#1417 Feature #1417

#1849 Feature #1849

#1014 Feature 1014

#1191 Feature 1191

#180 Feature #180

#1840 Feature #1840

#2107 Feature 2107

#466 Feature 466

#2939 Feature #2939

#2898 Feature 2898

#612 Feature 612

#2359 Feature #2359

#2505 Feature #2505

#877 Feature 877

#2649 Feature #2649

#1574 Feature 1574

#1864 Feature 1864

#2472 Feature 2472

#1949 Feature 1949

#1290 Feature 1290

#1216 Feature 1216

#1911 Feature #1911

#2137 Feature #2137

#3067 Feature 3067

#156 Feature 156

#713 Feature 713

#1541 Feature 1541

#102 Feature 102

#2431 Feature 2431

#1292 Feature 1292

#730 Feature 730

#569 Feature 569

#349 Feature #349

#847 Feature 847

#2435 Feature #2435

#452 Feature #452

#2249 Feature #2249

#451 Feature 451

#2540 Feature #2540

#2796 Feature #2796

#825 Feature #825

#1220 Feature 1220

#441 Feature 441

#2938 Feature #2938

#2403 Feature #2403

#2528 Feature #2528

#1472 Feature #1472

#2797 Feature 2797

#204 Feature #204

#931 Feature 931

#2315 Feature 2315

#853 Feature 853

#1449 Feature 1449

#666 Feature #666

#1689 Feature 1689

#962 Feature 962

#699 Feature 699

#1521 Feature #1521

#1977 Feature 1977

#1244 Feature #1244

#3005 Feature 3005

#2536 Feature 2536

#716 Feature #716

#556 Feature #556

#296 Feature 296

#2519 Feature 2519

#408 Feature #408

#2050 Feature 2050

#2482 Feature 2482

#2806 Feature 2806

#214 Feature #214

#959 Feature 959

#1859 Feature 1859

#2056 Feature 2056

#2101 Feature 2101

#1156 Feature #1156

#2042 Feature #2042

#2922 Feature 2922

#279 Feature 279

#1252 Feature 1252

#490 Feature 490

#480 Feature 480

#2385 Feature #2385

#2355 Feature 2355

#2259 Feature 2259

#2586 Feature 2586

#353 Feature 353

#1549 Feature 1549

#230 Feature #230

#2123 Feature 2123

#1690 Feature 1690

#128 Feature 128

#860 Feature #860

#1809 Feature #1809

#1759 Feature 1759

#418 Feature 418

#540 Feature 540

#2126 Feature #2126

#403 Feature 403

#2751 Feature #2751

#602 Feature 602

#1996 Feature #1996

#2186 Feature 2186

#2256 Feature 2256

#1161 Feature 1161

#1301 Feature 1301

#2940 Feature 2940

#2219 Feature #2219

#2139 Feature 2139

#2223 Feature 2223

#1096 Feature 1096

#1311 Molecular Mechanisms and Biological Processes

#2861 Feature 2861

#2263 Feature 2263

#2039 Feature 2039

#989 Feature #989

#593 Feature 593

#2361 Feature 2361

#2329 Feature #2329

#2731 Feature 2731

#2971 Feature #2971

#2023 Feature 2023

#625 Feature #625

#1079 Feature 1079

#1922 Feature 1922

#503 Feature 503

#368 Feature 368

#354 Feature 354

#2011 Feature 2011

#727 Feature 727

#2051 Feature #2051

#2813 Feature #2813

#2919 Feature 2919

#581 Feature 581

#14 Feature #14

#888 Feature 888

#921 Feature 921

#1524 Feature #1524

#1003 Feature 1003

#2111 Feature 2111

#170 Feature 170

#752 Feature 752

#164 Feature 164

#2010 Feature 2010

#1055 Feature 1055

#644 Feature 644

#2467 Feature 2467

#1231 Feature 1231

#552 Feature 552

#1471 Feature 1471

#2121 Feature 2121

#656 Feature #656

#2316 Feature #2316

#3043 Feature #3043

#498 Feature 498

#2466 Feature 2466

#2850 Feature 2850

#2297 Feature #2297

#2606 Feature #2606

#645 Feature #645

#1044 Feature 1044

#334 Feature 334

#2924 Feature 2924

#1933 Feature #1933

#1900 Feature 1900

#2074 Feature #2074

#1605 Feature 1605

#2176 Feature #2176

#3001 Feature 3001

#210 Feature 210

#834 Feature #834

#668 Feature 668

#1691 Feature 1691

#836 Feature 836

#2570 Feature 2570

#2913 Feature 2913

#2983 Feature #2983

#857 Feature 857

#109 Feature #109

#630 Feature 630

#457 Feature 457

#1340 Feature 1340

#2289 Feature #2289

#526 Feature #526

#1046 Feature #1046

#2117 Feature 2117

#2677 Feature 2677

#2822 Feature #2822

#1570 Feature #1570

#1347 Feature #1347

#824 Feature 824

#1813 Feature 1813

#896 Feature 896

#905 Feature #905

#1162 Feature 1162

#1214 Feature #1214

#2689 Feature 2689

#893 Feature 893

#557 Feature #557

#2562 Feature 2562

#2748 Feature #2748

#1070 Feature 1070

#689 Feature 689

#179 Feature 179

#141 Feature 141

#2029 Feature #2029

#2776 Feature 2776

#2496 Feature 2496

#2775 Feature #2775

#2082 Feature #2082

#1529 Feature 1529

#2085 Feature 2085

#682 Feature 682

#61 Feature #61

#566 Feature 566

#3037 Feature #3037

#339 Feature 339

#2350 Feature #2350

#259 Feature 259

#2490 Feature 2490

#111 Feature 111

#206 Feature #206

#1791 Feature 1791

#995 Feature 995

#787 Feature 787

#2417 Feature 2417

#1486 Feature #1486

#2879 Feature 2879

#2872 Feature 2872

#582 Feature 582

#393 Feature 393

#1641 Feature 1641

#2946 Feature 2946

#161 Feature 161

#2876 Feature #2876

#1862 Feature 1862

#1202 Feature #1202

#2225 Feature 2225

#2409 Feature #2409

#1051 Feature #1051

#2541 Feature #2541

#299 Feature 299

#1687 Feature 1687

#1470 Feature #1470

#742 Feature 742

#1111 Feature #1111

#985 Feature 985

#264 Feature 264

#2888 Feature 2888

#1708 Feature 1708

#1942 Feature #1942

#1595 Feature #1595

#1487 Feature #1487

#1106 Feature 1106

#2691 Feature 2691

#774 Feature 774

#2954 Feature #2954

#2073 Feature 2073

#367 Feature #367

#1189 Feature #1189

#2908 Feature 2908

#2296 Feature 2296

#145 Feature 145

#373 Feature 373

#2510 Feature 2510

#1649 Feature #1649

#1953 Feature 1953

#2304 Feature #2304

#793 Feature #793

#2993 Feature 2993

#2752 Feature 2752

#1361 Feature 1361

#794 Feature #794

#2245 Feature 2245

#1304 Feature 1304

#270 Feature 270

#2616 Feature 2616

#1112 Feature 1112

#2763 Feature 2763

#1645 Feature 1645

#2060 Feature 2060

#2411 Feature #2411

#698 Feature 698

#2331 Feature 2331

#616 Feature 616

#1001 Feature #1001

#1758 Feature 1758

#695 Feature #695

#2743 Feature 2743

#754 Feature 754

#2395 Feature 2395

#2742 Feature 2742

#1959 Feature #1959

#850 Feature #850

#434 Feature 434

#723 Feature 723

#926 Feature 926

#1635 Feature 1635

#387 Feature #387

#2708 Feature 2708

#669 Feature 669

#629 Feature #629

#1122 Feature #1122

#2130 Feature #2130

#704 Feature #704

#513 Feature 513

#673 Feature 673

#135 Feature 135

#1810 Feature 1810

#1438 Feature 1438

#2122 Feature 2122

#1609 Feature 1609

#533 Feature #533

#1714 Feature #1714

#1884 Feature #1884

#491 Feature 491

#522 Feature 522

#803 Feature #803

#231 Feature 231

#1981 Feature 1981

#1229 Feature #1229

#2866 Feature #2866

#2579 Feature #2579

#1709 Feature 1709

#2103 Feature #2103

#1950 Feature #1950

#289 Feature #289

#486 Feature 486

#107 Feature #107

#1752 Feature #1752

#1145 Feature #1145

#2679 Feature 2679

#281 Feature 281

#2174 Feature 2174

#1155 Feature 1155

#859 Feature 859

#790 Feature 790

#2929 Feature 2929

#1404 Feature #1404

#1720 Feature 1720

#2936 Feature 2936

#1654 Feature 1654

#2657 Feature 2657

#1506 Justification/Rationale for Actions

#2022 Feature 2022

#1468 Feature 1468

#635 Feature #635

#1967 Feature #1967

#822 Feature 822

#2446 Feature 2446

#2398 Feature 2398

#2284 Feature 2284

#1556 Feature #1556

#2047 Feature 2047

#1653 Feature 1653

#461 Feature 461

#547 Feature 547

#471 Feature #471

#1108 Feature 1108

#2406 Feature 2406

#2741 Feature 2741

#2148 Feature 2148

#2532 Feature 2532

#275 Feature #275

#2548 Feature 2548

#1199 Feature 1199

#2564 Feature 2564

#2504 Feature 2504

#245 Feature 245

#2344 Feature 2344

#1173 Feature #1173

#1711 Feature 1711

#2120 Feature 2120

#1497 Feature 1497

#2711 Feature #2711

#342 Feature 342

#1076 Feature #1076

#903 Feature 903

#2452 Feature 2452

#438 Feature 438

#379 Feature #379

#2962 Feature 2962

#1726 Feature 1726

#2261 Feature 2261

#2497 Feature 2497

#1539 Feature #1539

#1275 Feature #1275

#2378 Feature 2378

#2717 Feature 2717

#295 Feature 295

#3057 Feature #3057

#2317 Feature 2317

#1345 Feature 1345

#1103 Feature 1103

#1814 Feature 1814

#186 Feature #186

#2058 Feature #2058

#2221 Feature 2221

#1968 Feature 1968

#1508 Feature 1508

#2016 Feature 2016

#1748 Feature 1748

#1808 Feature 1808

#2293 Feature 2293

#1408 Feature #1408

#1456 Feature 1456

#2471 Feature 2471

#1978 Feature 1978

#2986 Feature #2986

#535 Feature 535

#1551 Feature 1551

Document Content

Polymer coatings that display specific biological signals while preventing nonspecific interactions.
Control over cell-material surface interactions is the key to many new and improved biomedical devices. It can only be achieved if interactions that are mediated by nonspecifically adsorbed serum proteins are minimized and if cells instead respond to specific ligand molecules presented on the surface. Here, we present a simple yet effective surface modification method that allows for the covalent coupling and presentation of specific biological signals on coatings which have significantly reduced nonspecific biointerfacial interactions. To achieve this we synthesized bottle brush type copolymers consisting of poly(ethylene glycol) methyl ether methacrylate and (meth)acrylates providing activated NHS ester groups as well as different spacer lengths between the NHS groups and the polymer backbone. Copolymers containing different molar ratios of these monomers were grafted to amine functionalized polystyrene cell culture substrates, followed by the covalent immobilization of the cyclic peptides cRGDfK and cRADfK using residual NHS groups. Polymers were characterized by GPC and NMR and surface modification steps were analyzed using XPS. The cellular response was evaluated using HeLa cell attachment experiments. The results showed strong correlations between the effectiveness of the control over biointerfacial interactions and the polymer architecture. They also demonstrate that optimized fully synthetic copolymer coatings, which can be applied to a wide range of substrate materials, provide excellent control over biointerfacial interactions.

Similar Documents