Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1483

MIN ACTIVATION

0.0

Details List

#150 Feature 150

#738 Feature 738

#1307 Feature 1307

#2790 Feature 2790

#2292 Feature 2292

#548 Feature 548

#1080 Feature 1080

#524 Feature 524

#923 Feature 923

#1004 Feature 1004

#1233 Feature 1233

#2592 Feature 2592

#439 Feature 439

#627 Feature 627

#708 Drug Resistance Mechanisms in Cancer

#1099 Feature 1099

#1905 Feature 1905

#2803 Feature 2803

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#636 Feature 636

#672 Feature 672

#1337 Feature 1337

#1452 Feature 1452

#3060 Feature 3060

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#374 Medical Imaging and Oncology

#1116 Feature 1116

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#1604 Feature 1604

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#405 Feature 405

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#3030 Feature 3030

#1009 Feature 1009

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#1920 Feature 1920

#1114 Feature 1114

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#2797 Feature 2797

#2566 Feature 2566

#2582 Feature 2582

#579 Feature 579

#1304 Feature 1304

#2589 Feature 2589

#383 Feature 383

#2460 Feature 2460

#2291 Feature 2291

#1792 Metastatic Cancer

#2340 Feature 2340

#2623 Feature 2623

#1200 Feature 1200

#2076 Feature 2076

#1719 Feature 1719

#2408 Feature 2408

#284 Feature 284

#1866 Feature 1866

#723 Feature 723

#219 Feature 219

#2977 Feature 2977

#1006 Feature 1006

#2350 Feature 2350

#979 Feature 979

#1582 Feature 1582

#379 Feature 379

#1657 Feature 1657

#2419 Feature 2419

#253 Feature 253

#2985 Feature 2985

#2028 Feature 2028

#1425 Feature 1425

#2758 Feature 2758

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#1965 Feature 1965

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#2206 Feature 2206

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#1631 Feature #1631

#2601 Feature 2601

#566 Feature 566

#2905 Feature 2905

#2293 Feature 2293

#766 Feature 766

#884 Feature 884

#1515 Feature 1515

#581 Feature 581

#1516 Feature 1516

#410 Feature 410

#2598 Feature 2598

#1843 Feature 1843

#283 Feature 283

#1386 Feature 1386

#2323 Feature 2323

#703 Feature 703

#815 Feature 815

#1683 Feature 1683

#1625 Feature 1625

#1993 Feature 1993

#3037 Feature 3037

#430 Feature 430

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#2033 Feature 2033

#2780 Feature 2780

#1914 Feature 1914

#1469 Feature 1469

#699 Feature 699

#2822 Feature 2822

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#2792 Feature 2792

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#2702 Feature 2702

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#2885 Feature 2885

#363 Feature 363

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#1709 Feature 1709

#1946 Feature 1946

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#841 Feature 841

#2074 Feature 2074

#350 Feature 350

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#298 Feature 298

#2863 Feature 2863

#2802 Feature 2802

#172 Feature 172

#1195 Feature 1195

#107 Feature 107

#2471 Feature 2471

#2069 Feature 2069

#1378 Feature 1378

#639 Feature 639

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#2737 Feature 2737

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#2510 Feature 2510

#1821 Feature 1821

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#711 Feature 711

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#2502 Feature 2502

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#2966 Feature 2966

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#2142 Feature 2142

#1760 Feature 1760

#1544 Feature 1544

#144 Feature 144

#511 Feature 511

#695 Feature 695

#1714 Feature 1714

#2083 Feature 2083

#947 Feature 947

#1677 Feature 1677

#2232 Medical Case Reports & Cancer Research

#475 Feature 475

#760 Feature 760

#1695 Feature 1695

#2177 Feature 2177

#2759 Feature 2759

#3009 Feature 3009

#2613 Feature 2613

#1759 Feature 1759

#629 Feature 629

#1414 Feature 1414

#1161 Feature 1161

#1750 Feature 1750

#1147 Feature 1147

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#1870 Feature 1870

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#2496 Feature 2496

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#2913 Feature 2913

#1829 Feature 1829

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#1247 Feature 1247

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#215 Feature 215

#648 Feature 648

#1255 Feature 1255

#2230 Feature 2230

#2495 Feature 2495

#2657 Feature 2657

#1245 Feature 1245

#1113 Feature 1113

#1476 Feature 1476

#2936 Feature 2936

#1352 Feature 1352

#211 Feature 211

#1079 Feature 1079

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#673 Feature 673

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#2309 Feature 2309

#2399 Feature 2399

#2567 Feature 2567

#2021 Feature 2021

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#3033 Feature 3033

#1804 Feature 1804

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#127 Feature 127

#1964 Feature 1964

#2937 Feature 2937

#1778 Feature 1778

#2127 Feature 2127

#2467 Feature 2467

#427 Feature 427

#2783 Feature 2783

#2786 Feature 2786

#2770 Feature 2770

#279 Feature 279

#2635 Feature 2635

#615 Feature 615

#437 Feature 437

#1700 Feature 1700

#337 Feature 337

#1962 Feature 1962

#1968 Feature 1968

#997 Feature 997

#2160 Feature 2160

#968 Feature 968

#2284 Feature 2284

#1885 Feature 1885

#165 Feature 165

#1317 Feature 1317

#1192 Feature 1192

#1434 Feature 1434

#1680 Feature 1680

#2957 Feature 2957

#973 Feature 973

#1087 Feature 1087

#2549 Feature 2549

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#691 Feature 691

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#1082 Feature 1082

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#1901 Feature 1901

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#1805 Feature 1805

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#2147 Feature 2147

#2436 Feature 2436

#1093 Feature 1093

#421 Feature 421

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#2616 Feature 2616

#2473 Feature 2473

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#218 Feature 218

#2732 Feature 2732

#1237 Feature 1237

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#977 Feature 977

#2925 Feature 2925

#202 Feature 202

#2394 Feature 2394

#1793 Feature 1793

#1671 Feature 1671

#1140 Feature 1140

#2280 Feature 2280

#1796 Feature 1796

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#642 Feature 642

#1973 Feature 1973

#2014 Feature 2014

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#1523 Feature 1523

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#2632 Feature 2632

#2401 Feature 2401

#2524 Feature 2524

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#755 Feature 755

#238 Feature 238

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#1209 Feature 1209

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#2491 Feature 2491

#2132 Feature 2132

#1238 Feature 1238

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#241 Feature 241

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#2266 Feature 2266

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#240 Feature 240

#115 Feature 115

#222 Feature 222

#1039 Feature 1039

#2306 Feature 2306

#190 Feature 190

#1883 Feature 1883

#1539 Feature 1539

#2221 Feature 2221

#2453 Feature 2453

#151 Feature 151

#2086 Feature 2086

#133 Feature 133

#1205 Feature 1205

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#483 Feature 483

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#2358 Feature 2358

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#276 Feature 276

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#1801 Feature 1801

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#2079 Feature 2079

#1171 Feature 1171

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#1448 Feature 1448

#1391 Feature 1391

#630 Feature 630

#2734 Feature 2734

#1977 Feature 1977

#2612 Feature 2612

#978 Feature 978

#2523 Feature 2523

#1527 Feature 1527

#1481 Feature 1481

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#1482 Feature 1482

#2540 Feature 2540

#1400 Feature 1400

#1628 Feature 1628

#2651 Feature 2651

#847 Feature 847

#1196 Feature 1196

#2963 Feature 2963

#1903 Feature 1903

#1130 Feature 1130

#733 Feature 733

#2961 Feature 2961

#1295 Feature 1295

#2940 Feature 2940

#1869 Feature 1869

#2890 Feature 2890

#2027 Feature 2027

#1967 Feature 1967

#2672 Feature 2672

#1280 Feature 1280

#2368 Feature 2368

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#2677 Feature 2677

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#2227 Feature 2227

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#1014 Feature 1014

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#1588 Feature 1588

#2479 Feature 2479

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#392 Feature 392

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#2848 Feature 2848

#2116 Feature 2116

#1636 Feature 1636

#1419 Feature 1419

#210 Feature 210

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#960 Feature 960

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#735 Feature 735

#3019 Feature 3019

#1972 Feature 1972

#1758 Feature 1758

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#251 Feature 251

#1716 Feature 1716

#435 Feature 435

#1638 Feature 1638

#1985 Feature 1985

#2990 Feature 2990

#2199 Feature 2199

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#1627 Feature 1627

#1050 Feature 1050

#231 Feature 231

#1264 Feature 1264

#958 Feature 958

#719 Feature 719

#805 Feature 805

#1611 Feature 1611

#1752 Feature 1752

#234 Feature 234

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#2134 Feature 2134

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#2828 Feature 2828

#2234 Feature 2234

#1415 Feature 1415

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#675 Feature 675

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#2573 Feature 2573

#2166 Feature #2166

#860 Feature 860

#808 Feature 808

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#2456 Feature 2456

#105 Feature 105

#2979 Feature 2979

#580 Feature 580

#389 Feature 389

#1882 Feature 1882

#1248 Feature 1248

#2125 Feature 2125

#400 Feature 400

#2018 Feature 2018

#517 Feature 517

#1925 Feature 1925

#543 Feature 543

#438 Feature 438

#1768 Feature 1768

#819 Feature 819

#1984 Feature 1984

#2153 Feature 2153

#2652 Feature 2652

#267 Feature 267

#2489 Feature 2489

#1780 Feature 1780

#2686 Feature 2686

#2233 Feature 2233

#810 Feature 810

#2788 Feature 2788

#1892 Feature 1892

#2753 Feature 2753

#1834 Feature 1834

#1998 Feature 1998

#1218 Feature 1218

#1286 Feature 1286

#23 Neuronal Circuitry and Cellular Processes

#1897 Feature 1897

#1206 Feature 1206

#1013 Feature 1013

#1526 Feature 1526

#677 Feature 677

#539 Feature 539

#244 Feature 244

#1103 Feature 1103

#1243 Feature 1243

#2223 Feature 2223

#2439 Feature 2439

#1066 Feature 1066

#254 Feature 254

#149 Feature 149

#1250 Feature 1250

#452 Feature 452

#373 Feature 373

#2243 Feature 2243

#1578 Feature 1578

#2042 Feature 2042

#2334 Feature 2334

#2704 Feature 2704

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#845 Feature 845

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#1535 Feature 1535

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#3041 Feature 3041

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#1042 Feature 1042

#167 Feature 167

#2339 Feature 2339

#1900 Feature 1900

#2525 Feature 2525

#1139 Feature 1139

#2583 Feature 2583

#2698 Feature 2698

#1976 Feature 1976

#305 Feature 305

#991 Feature 991

#114 Feature 114

#2638 Feature 2638

#2637 Feature 2637

#303 Feature 303

#1435 Feature 1435

#256 Feature 256

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#2824 Feature 2824

#739 Feature 739

#2361 Feature 2361

#1166 Feature 1166

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#1279 Feature 1279

#769 Feature 769

#356 Feature 356

#780 Feature 780

#1312 Feature 1312

#413 Feature 413

#1644 Feature 1644

#3045 Feature 3045

#2663 Feature 2663

#1187 Feature 1187

#1572 Feature 1572

#2462 Feature #2462

#2039 Feature 2039

#495 Feature 495

#1002 Feature 1002

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#100 Feature 100

#1966 Feature 1966

#1214 Feature 1214

#221 Feature #221

#831 Feature 831

#1552 Feature 1552

#1142 Feature 1142

#2331 Feature 2331

#2621 Feature 2621

#1240 Feature 1240

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#2255 Feature 2255

#522 Feature 522

#2088 Feature 2088

#187 Feature 187

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#2427 Feature 2427

#2376 Feature 2376

#938 Feature 938

#2260 Historical Context & Development

#2624 Feature 2624

#1274 Feature 1274

#1919 Feature 1919

#2452 Feature 2452

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#2224 Feature 2224

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#2931 Feature 2931

#388 Feature 388

#1431 Feature 1431

#2464 Feature 2464

#176 Feature 176

#1441 Feature 1441

#2795 Feature 2795

#1727 Feature 1727

#1062 Feature 1062

#1465 Feature 1465

#2371 Feature 2371

#982 Feature 982

#2070 Feature 2070

#1852 Feature 1852

#2270 Feature 2270

#1421 Feature 1421

#1528 Feature 1528

#2928 Feature 2928

#2268 Feature 2268

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#1156 Feature 1156

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#2841 Feature 2841

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#139 Feature 139

#1201 Feature 1201

#1474 Feature 1474

#401 Feature 401

#2104 Feature 2104

#2041 Feature 2041

#2816 Feature 2816

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#1888 Feature 1888

#2917 Feature 2917

#447 Feature 447

#3022 Feature 3022

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#1682 Feature 1682

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#2077 Feature 2077

#2414 Feature 2414

#729 Feature 729

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#403 Feature 403

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#2204 Feature 2204

#2506 Feature #2506

#2174 Feature 2174

#2980 Feature 2980

#1457 Feature 1457

#205 Feature 205

#837 Feature 837

#2171 Molecular and Cellular Biological Processes

#2319 Feature 2319

#1571 Feature 1571

#386 Feature 386

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#641 Feature 641

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#1609 Feature 1609

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#180 Feature 180

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#2503 Feature 2503

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#1263 Feature 1263

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#3011 Feature 3011

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#1521 Feature #1521

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#3000 Feature 3000

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#2316 Feature #2316

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#351 Nanomaterial Synthesis and Properties

#1715 Feature 1715

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#1489 Feature 1489

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#345 Feature 345

#2190 Feature 2190

#2002 Feature 2002

#2660 Feature 2660

#669 Feature 669

#1506 Justification/Rationale for Actions

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#922 Feature 922

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#866 Feature 866

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#1613 Feature 1613

#1044 Feature 1044

#2348 Feature 2348

#161 Feature 161

#1081 Feature 1081

#1724 Feature 1724

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Document Content

The role of p21-activated kinases in pancreatic cancer.
Pancreatic cancer is an aggressive cancer with a poor prognosis and an overall 5-year survival rate of less than 5%. Management has not improved significantly over the last 30 years, and a better understanding of the genetic and molecular changes that occur is urgently required. Many of these changes appear to involve the p21-activated kinases (PAKs). The PAK family consists of 6 isoforms, 2 of which, PAK1 and PAK4, are up-regulated and/or hyperactivated in pancreatic cancer. p21-Activated kinases can mediate many different cellular processes especially those contributing to cancer development and progression. These processes include the regulation of cytoskeletal dynamics and cell adhesion, the evasion of apoptosis, and the promotion of cell survival, proliferation, migration, and invasion. p21-Activated kinases may also be involved in characteristics unique to pancreatic tumors, such as interplay with the pancreatic stroma, the re-emergence of embryonic pathways, and the involvement of a subset of microRNAs and heat shock proteins. This review highlights the potential role of PAKs in pancreatic cancer and provides a foundation for more effective therapeutics to improve our current treatment of pancreatic cancer.

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