Documento #89

Processato

Contenuto Testuale

The use of laboratory biomarkers for surveillance, diagnosis and prediction of clinical outcomes in neonatal sepsis and necrotising enterocolitis.
Biomarkers have been used to differentiate systemic neonatal infection and necrotising enterocolitis (NEC) from other non-infective neonatal conditions that share similar clinical features. With increasing understanding in biochemical characteristics of different categories of biomarkers, a specific mediator or a panel of mediators have been used in different aspects of clinical management in neonatal sepsis/NEC. This review focuses on how these biomarkers can be used in real-life clinical settings for daily surveillance, bedside point-of-care testing, early diagnosis and predicting the severity and prognosis of neonatal sepsis/NEC. In addition, with recent development of 'multi-omic' approaches and rapid advancement in knowledge of bioinformatics, more novel biomarkers and unique signatures of mediators would be discovered for diagnosis of specific diseases and organ injuries.

Vettore Embedding

[0.0010227441, 0.015711272, -0.020573419, 0.029872699, 0.06434587, ... ]

Dimensioni 768 dim
Creato il 31/03/2026 15:19
Model

[0.0010227441, 0.015711272, -0.020573419, 0.029872699, 0.06434587, 0.0501562, -0.03463236, 0.060281217, -0.032164972, -0.0076541346, 0.009981561, 0.03207105, -0.009527107, -0.0017088791, -0.032787412, -0.0049172128, -0.02951568, 0.056280978, 0.003575641, 0.010641391, 0.021557389, 0.005392136, -0.02681883, -0.034731667, 0.075852744, 0.022917876, 0.018101795, -0.0024323368, 0.03272999, 0.014789709, 0.04541175, 0.02097408, 0.001020241, 0.06445831, 0.02931439, 0.0071156896, 0.0013260006, -0.063642845, 0.05192665, -0.03291906, -0.003153026, 0.06133646, -0.022497518, 0.055376694, 0.030643728, -0.0057380036, -0.04547738, -0.049592055, -0.020386156, -0.010098322, 0.011548721, 0.0031247714, -0.037988912, 0.051933605, 0.031099485, 0.052310284, -0.018918395, -0.0069579952, 0.015798276, 0.04583237, -0.048507255, -0.014488285, -0.027615651, -0.053326283, 0.073204875, 0.05541971, -0.031083854, -0.03265098, 0.026962157, 0.12159892, -0.00797424, 0.0500334, -0.0051056775, 0.014128895, 0.09635119, 0.0051357225, -0.0035349992, 0.019558867, -0.029636674, 0.09920177, -0.022801263, 0.029998507, 0.05252475, 0.00566282, 0.109843634, -0.03384233, -0.042712554, -0.032038543, 0.02152423, -0.008288235, -0.034927085, 0.023760956, -0.033616964, 0.025972534, 0.013902648, -0.046404306, 0.005868815, -0.0480749, 0.0018388417, -0.05830819, 0.014834107, 0.012531929, 0.002459916, 0.07693418, 0.054166168, 0.0521253, 0.018876607, -0.00019913119, -0.013603821, 0.06605168, -0.043300472, 0.03427172, -0.03494108, -0.04047095, 0.0046273745, -0.037007917, 0.016930023, 0.033014163, 0.026516585, 0.026881631, -0.028083153, -0.011470126, 0.01394423, -0.01384137, 0.035963513, -0.025909366, -0.026710166, 0.042645767, 0.033795204, 0.033504352, 0.012038002, 0.047643695, -0.048280865, 0.04142639, -0.0028110673, 0.0621885, -0.003036679, -0.038257413, 0.013447423, -0.0608928, 0.02227452, -0.053757694, 0.0005069462, -0.02580361, 0.059890598, -0.0033483142, -0.041680936, 0.010013834, 0.0582592, 0.0208676, -0.05936244, -0.015666608, 0.008014058, -0.021631071, -0.025536956, -0.078567736, -0.031224966, -0.03145189, 0.037156794, -0.033207774, -0.051386148, -0.057824574, -0.043971304, -0.0049802386, 0.08220216, 0.06251566, -0.01418971, 0.06440235, -0.0056240344, 0.065640785, -0.0035974316, -0.033173487, -0.012888893, 0.02440907, 0.016195793, 0.03850965, -0.029597089, -0.013334071, 0.013530973, 0.011404776, -0.049261793, 0.024466675, -0.044606313, 0.02590001, 0.010739697, 0.045975763, -0.031862002, 0.030841416, -0.036203254, 0.008350282, 0.028139204, -0.008546278, 0.03853625, 0.013016033, 0.022007558, -0.017142393, 0.022084674, -0.0026367398, -0.01470649, 0.034321275, -0.02267827, -0.0993461, 0.039015654, 0.027654536, -0.0049196454, -0.026192538, -0.04508225, 0.0041212286, -0.01771664, 0.08585068, 0.04426791, -0.0008356131, 0.012225494, 0.030353444, -0.048603557, -0.032607805, -0.044147052, -0.023477083, 0.058760475, -0.055686653, -0.05585349, 0.024454366, 0.043452904, -0.046277978, -0.05137866, 0.010500144, -0.08469683, 0.031159027, 0.02838393, -0.06453422, 0.0279857, -0.03978642, -0.030643515, 0.022419225, -0.058203615, 0.048913665, -0.024367178, -0.017709406, 0.02411734, 0.023505086, 0.01827474, -0.075879, 0.03920866, 0.021107625, 0.0022390904, 0.07652692, -0.019235265, -0.08994096, 0.04405414, -0.021322729, -0.028672103, 0.0045807716, 0.043948144, 0.075064704, 0.035218596, -0.027826687, -0.028778514, 0.018975351, -0.027848467, 0.032484233, -0.008883488, 0.014671945, 0.0012005279, -0.037134405, 0.010190553, 0.023587916, 0.029849062, -0.047080908, -0.0017748378, 0.024211563, 0.0046032383, 0.028088015, -0.0076418547, -0.08035406, -0.034720197, 0.03595966, -0.0056854533, 0.0039165043, -0.016784336, -0.015662968, 0.010951017, -0.011568359, -0.0044020046, -0.0047120685, 0.024205321, 0.029685056, -0.01649465, -0.007930698, 0.042033747, 0.031749547, 0.053172555, 0.008728404, -0.0018076152, -0.0052363966, 0.025052845, -0.054054644, -0.031120969, 0.016299726, -0.011760684, 0.011370489, 0.103836015, 0.01468689, 0.0074976343, -0.010333194, 0.029831558, -0.0041524754, -0.059842467, 0.048922475, -0.034452528, 0.03713684, 0.023012634, -0.011423094, 0.053120285, 0.01437038, 0.032155402, -0.04553402, -0.01428647, -0.05362727, -0.04310063, 0.07633189, -0.017677082, -0.02661303, -0.0068647983, 0.062226817, 0.039892055, 0.010841223, 0.004706827, -0.042401936, -0.021980219, -0.0031340795, -0.0010349804, -0.02438017, 0.06858517, -0.039094657, -0.04361075, 0.03659773, 0.022644604, -0.0054225964, -0.012837712, -0.023446381, 0.047848713, -0.00072673487, 0.02285466, 0.019406332, -0.025760198, 0.0069630053, 0.0054737907, 0.007502911, 0.0101573765, 0.0012229047, 0.013716377, -0.01936195, -0.05080014, 0.0055101514, -0.046551146, 0.06444567, 0.0143832825, -0.017581536, 0.03874299, -0.013646852, 0.04478895, 0.013720475, 0.038906563, -0.07362554, -0.0050973454, -0.05703882, 0.037734702, -0.014505432, 0.083446555, 0.008604511, -0.021083046, 0.043232806, 0.06468196, -0.021122193, -0.046136178, -0.07617137, -0.02411321, 0.019086253, -0.0026982394, -0.038516317, 0.007914672, 2.4335759e-05, 0.009026051, 0.02448931, 0.07186055, 0.02712002, 0.01241194, -0.013053132, 0.054065775, 0.0077947713, -0.085303314, 0.045342408, 0.02179492, -0.014521672, -0.011598775, -0.009424615, 0.009880281, 0.005216302, -0.00039683707, -0.04193465, 0.011798913, -0.020057816, -0.04173422, 0.0009829082, 0.02664039, 0.004878082, 0.010119726, 0.0055253, 0.017154742, -0.027137805, 0.018388525, -0.03885039, -0.018290054, -0.033602733, -0.075812645, -2.4370202e-05, -0.015848685, 0.05006821, -0.026656335, -0.02793808, 0.021181999, 0.0066678226, 5.310246e-05, 0.07587749, -0.0033113984, 0.016393289, 0.034130275, -0.06016866, 0.024531879, -0.015283272, -0.028186278, -0.030471105, -0.037718292, 0.011950659, 0.019269742, -0.012019172, -0.048288316, -0.04774466, 0.004354223, 0.026294997, 0.02354239, -0.06925695, -0.0066787475, 0.0032940733, -0.040195003, 0.011110896, -0.020590417, -0.07811637, -0.06663159, 0.012854594, 0.048045956, 0.042198602, 0.029420262, -0.021101087, -0.01852627, 0.046618376, -0.014078558, 0.024924055, 0.021018052, 0.015603693, 0.037859887, -0.017913248, -0.03029091, -0.054903556, -0.01184442, -0.047189955, -0.021373281, -0.001055322, 0.049027197, 0.036226377, 0.08434139, 0.016076392, 0.035445295, -0.023528382, -0.02909074, -0.019466987, -0.03627218, 0.00258469, -0.034041964, 0.003799868, 0.040780973, -0.03719934, 0.0041166553, -0.01748189, 0.009085614, 0.05138616, -0.010304076, 0.042767584, -0.08562471, -0.007066166, 0.038616035, 0.016392734, 0.012973231, 0.021749858, -0.0010482636, 0.019112946, 0.010295504, 0.029987834, -0.010890345, 0.035225604, -0.060669538, 0.0213018, -0.039839264, -0.023664627, -0.07748456, -0.053372715, -0.054419205, -0.01833012, -0.0396438, 0.024189865, -0.027661487, 0.027309347, -0.073820345, -0.0104864035, 0.03138993, -0.0014791366, 0.021418475, -0.0034701214, -0.024273915, -0.020194748, -0.03574676, 0.058578413, 0.06541649, 0.04630118, -0.007672836, 0.062311936, -0.024289375, 0.031081354, 0.061704982, 0.027176833, 0.0113165565, 0.013006241, 0.0020849006, 0.01015639, -0.0163489, 0.012175831, 0.032492444, -0.08936828, -0.026181694, -0.039385892, -0.049283687, -0.028529245, -0.034376673, 0.056007244, 0.02285464, -0.0048732804, -0.0009804671, -0.05663126, 0.035520036, 0.01831802, 0.04081665, 0.0040001213, -0.017090175, -0.022226663, -0.011936655, 0.022560861, 0.00021641635, -0.000518835, -0.013771755, -0.056727897, -0.024185678, -0.005015934, 0.030432811, 0.015343994, 0.009279212, -0.016441055, 0.018941171, -0.039592855, -0.03290948, 0.010868119, -0.02130945, -0.01992562, 0.092257224, 0.012239204, -0.031822234, -0.01297794, -0.029250534, 0.02016362, -0.046735287, -0.09858544, -0.029221602, 0.045586146, 0.0095421495, 0.006059925, -0.015207775, -0.028102465, 0.07579597, -0.049916036, -0.0058415597, -0.027479876, -0.047808927, -0.05557562, -0.0027533546, 0.016589291, -0.031133069, -0.025404971, -0.068497084, 0.015965823, 0.019756455, 0.08092131, 0.011814341, 0.001051056, 0.04471089, -0.002479906, 0.047769573, -0.08958106, 0.033850458, 0.032682627, 0.028078996, 0.047607396, 0.028466372, 0.020321943, 0.0052799652, 0.0018835596, -0.009089282, 0.0013802092, -0.047815405, 0.052642096, 0.015223806, 0.0036667383, 0.004694362, -0.0012188002, 0.054688588, 0.0068203197, 0.059239186, -0.016453877, 0.0081929155, 0.08932195, -0.028634442, 0.00957413, -0.038475137, 0.030062713, 0.03275613, -0.018086333, 0.038315546, -0.04797805, -0.0012652032, -0.064625144, -0.030590806, 0.019402364, -0.024076289, -0.023700615, 0.04903288, 0.008862155, -0.055601925, 0.0448053, -0.03124678, -0.040432036, -0.016506959, -0.025324265, 0.023811594, -0.04041333, -0.005699719, -0.012458471, -0.016860563, 0.009233859, -0.04223084, 0.014097647, 0.006347565, 0.037665095, -0.06819235, 0.016011, 0.01161938, 0.0072659943, -0.010183114, 0.010607019, -0.017575243, -0.02766664, -0.024491785, 0.015461333, -0.017893326, -0.052635804, -0.07527143, 0.030066093, 0.0029345772, -0.00305226, -0.029860416, -0.016591944, -0.03828999, 0.0018036492, -0.0080102105, 0.038803056, 0.033481624, 0.002726895, -0.0019721733, 0.0067801466, -0.044903196, -0.010211159, 0.04398332, -0.043631785, 0.003672637, 0.0352615, -0.011815478, 0.0043269885, -0.049902324, 0.032462373, 0.028101986, 0.030431107, 0.025190398, 0.057718705, -0.014486909, 0.019948678, 0.026624735, 0.015895288, 0.009374388, 0.0051971073, -0.009383825, 0.01440332, 0.010399112, -0.026196832, -0.04089487, 0.027245631, -0.03249338, 0.03460092, -0.040142287, -0.000910765, -0.013373491, -0.025165455, 0.033204157, -0.05149617, 0.031998485, -0.055365436, 0.05553239, -0.0093443515, -0.027646292, 0.036232244, -0.02649175, 0.025110697, 0.015908772, -0.042501047, -0.07688048, 0.028540287, -0.049565397, -0.041357033, 0.020177417, 0.052057724, 0.040869456, -0.02080656, 0.042006932, -0.007751116, 0.013257584, 0.0042619132, -0.024792342, 0.00021434978, 0.045997445, 0.06007755, -0.033485897, -0.006628028, 0.062277213, 0.030155586, 0.024944535, 0.04556469, -0.0012064581, 0.013327049, 0.0154685825, -0.03815789, 0.017328618, 0.008032684, 0.031077087, 0.0093355635, -0.055280976, 0.039614495, 0.0032838488, -0.036073044, -0.00693941, 0.030802093, 0.020337125, 0.015593085]